Polyamine–DNA Interactions: Possible Site of New Cancer Chemotherapeutic Intervention

Laurence J. Marton, Burt G. Feuerstein

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The effects of polyamines on the structure of nucleic acids in cell-free systems and in cell culture systems are reviewed. Evidence suggests that polyamine depletion inhibits cell growth and may cause conformational changes in DNA. These effects may be exploited to cause changes in the action of drugs and may be used to advantage in combination treatment protocols. A discussion of theoretical models of the interactions, physicochemical evidence for conformational changes, and the effects of anticancer drugs in cells depleted of polyamines is presented.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Volume3
Issue number6
DOIs
StatePublished - Dec 1986
Externally publishedYes

Keywords

  • cancer chemotherapy
  • molecular modeling
  • nucleic acid conformation
  • nucleic acids
  • polyamines

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

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