Polymorphism of human telomeric quadruplex structures

Jixun Dai, Megan Carver, Danzhou Yang

Research output: Contribution to journalReview article

287 Scopus citations

Abstract

Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism of human telomeric sequences and its implications for drug targeting.

Original languageEnglish (US)
Pages (from-to)1172-1183
Number of pages12
JournalBiochimie
Volume90
Issue number8
DOIs
StatePublished - Aug 1 2008

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Keywords

  • Anticancer drug target
  • G-quadruplex
  • Human telomere
  • NMR
  • Potassium structure
  • Structure polymorphism

ASJC Scopus subject areas

  • Biochemistry

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