Polymorphisms in the CD14 gene associated with pulmonary function in farmers

Tricia D. LeVan, Susanna Von Essen, Debra J. Romberger, G. Patrick Lambert, Fernando D. Martinez, Monica M. Vasquez, James A. Merchant

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Rationale and Objectives: Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin. Materials and Methods: Based on our findings of increased circulating CD14 associated with the CD14/ -159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin-exposed individuals. CD14/-159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and mean forced expiratory flow during the middle half of the FVC (FEF25-75) (p = 0.05) compared with farmers with the C allele (n = 78). Also, farmers with the CD14/-1619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25-75, p = 0.009) compared with farmers with the A allele (n = 86). Results: No association between CD14/-550 and lung function was observed (FEV1, p = 0.32; FEF25-75, p = 0.11). Increased prevalence of wheezing was reported in farmers homozygous for CD14/-159T (p = 0.013) or CD14/-1619G (p = 0.019) compared with farmers with the CC or AA genotype, respectively. No association was found between TLR4/Asp299Gly and lung function or wheeze. Conclusion: We conclude that the CD14/-159 or CD14/-1619 loci may play a role in modulating lung function and wheeze among agricultural workers.

Original languageEnglish (US)
Pages (from-to)773-779
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume171
Issue number7
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

Keywords

  • Endotoxin
  • Farming
  • Lipopolysaccharide
  • Occupational exposure
  • Wheeze

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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