Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry

Andrew W. Bismark, Francisco Moreno, Jennifer L. Stewart, David N. Towers, James A. Coan, Jennifer Oas, Robert P. Erickson, John JB Allen

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Polymorphic variations in genes related to serotonin synthesis, transport, recognition, or degradation may convey subtle changes in serotonin system architecture that may place an individual at risk for psychopathology when faced with life stressors. The relationship between three key serotonin alleles and frontal brain electrical asymmetry, a putative endophenotype of depression, was examined. Risk alleles were hypothesized to predict relatively greater right frontal brain activity regardless of current clinical state. A sample of 313 college-age individuals, spanning a range of depressive severity from no symptomotology to clinically meaningful levels, participated. Resting encephalographic (EEG) activity was recorded from 64 scalp sites on four occasions separated by at least 24. h (two 8-min recording sessions occurring at each occasion). Alpha power asymmetry scores between homologous sites were calculated for each session and then averaged to form a trait metric of asymmetry for each pair. PCR based genotyping was conducted for the HTR1a, HTR2a, and HTTLPR genes. Variations in the HTR1a gene were related to trait EEG asymmetry, regardless of any history of depression. Compared to subjects with at least one non-risk allele, subjects with homozygous HTR1A risk alleles had significantly greater relative right frontal activity at sites F7/F8, F5/F6, and F1/F2. In conclusion, variation in HTR1a can influence trait level brain activity, which may ultimately be indicative of risk for psychopathology.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalBiological Psychology
Volume83
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Alleles
Serotonin
Brain
Psychopathology
Depression
Genes
Endophenotypes
Scalp
Polymerase Chain Reaction

Keywords

  • Asymmetry
  • EEG
  • Endophenotype
  • Gene
  • HTR1a
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry. / Bismark, Andrew W.; Moreno, Francisco; Stewart, Jennifer L.; Towers, David N.; Coan, James A.; Oas, Jennifer; Erickson, Robert P.; Allen, John JB.

In: Biological Psychology, Vol. 83, No. 2, 02.2010, p. 153-158.

Research output: Contribution to journalArticle

Bismark, Andrew W. ; Moreno, Francisco ; Stewart, Jennifer L. ; Towers, David N. ; Coan, James A. ; Oas, Jennifer ; Erickson, Robert P. ; Allen, John JB. / Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry. In: Biological Psychology. 2010 ; Vol. 83, No. 2. pp. 153-158.
@article{d046313c66c842ec8de493625c79fe19,
title = "Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry",
abstract = "Polymorphic variations in genes related to serotonin synthesis, transport, recognition, or degradation may convey subtle changes in serotonin system architecture that may place an individual at risk for psychopathology when faced with life stressors. The relationship between three key serotonin alleles and frontal brain electrical asymmetry, a putative endophenotype of depression, was examined. Risk alleles were hypothesized to predict relatively greater right frontal brain activity regardless of current clinical state. A sample of 313 college-age individuals, spanning a range of depressive severity from no symptomotology to clinically meaningful levels, participated. Resting encephalographic (EEG) activity was recorded from 64 scalp sites on four occasions separated by at least 24. h (two 8-min recording sessions occurring at each occasion). Alpha power asymmetry scores between homologous sites were calculated for each session and then averaged to form a trait metric of asymmetry for each pair. PCR based genotyping was conducted for the HTR1a, HTR2a, and HTTLPR genes. Variations in the HTR1a gene were related to trait EEG asymmetry, regardless of any history of depression. Compared to subjects with at least one non-risk allele, subjects with homozygous HTR1A risk alleles had significantly greater relative right frontal activity at sites F7/F8, F5/F6, and F1/F2. In conclusion, variation in HTR1a can influence trait level brain activity, which may ultimately be indicative of risk for psychopathology.",
keywords = "Asymmetry, EEG, Endophenotype, Gene, HTR1a, Serotonin",
author = "Bismark, {Andrew W.} and Francisco Moreno and Stewart, {Jennifer L.} and Towers, {David N.} and Coan, {James A.} and Jennifer Oas and Erickson, {Robert P.} and Allen, {John JB}",
year = "2010",
month = "2",
doi = "10.1016/j.biopsycho.2009.12.002",
language = "English (US)",
volume = "83",
pages = "153--158",
journal = "Biological Psychology",
issn = "0019-493X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Polymorphisms of the HTR1a allele are linked to frontal brain electrical asymmetry

AU - Bismark, Andrew W.

AU - Moreno, Francisco

AU - Stewart, Jennifer L.

AU - Towers, David N.

AU - Coan, James A.

AU - Oas, Jennifer

AU - Erickson, Robert P.

AU - Allen, John JB

PY - 2010/2

Y1 - 2010/2

N2 - Polymorphic variations in genes related to serotonin synthesis, transport, recognition, or degradation may convey subtle changes in serotonin system architecture that may place an individual at risk for psychopathology when faced with life stressors. The relationship between three key serotonin alleles and frontal brain electrical asymmetry, a putative endophenotype of depression, was examined. Risk alleles were hypothesized to predict relatively greater right frontal brain activity regardless of current clinical state. A sample of 313 college-age individuals, spanning a range of depressive severity from no symptomotology to clinically meaningful levels, participated. Resting encephalographic (EEG) activity was recorded from 64 scalp sites on four occasions separated by at least 24. h (two 8-min recording sessions occurring at each occasion). Alpha power asymmetry scores between homologous sites were calculated for each session and then averaged to form a trait metric of asymmetry for each pair. PCR based genotyping was conducted for the HTR1a, HTR2a, and HTTLPR genes. Variations in the HTR1a gene were related to trait EEG asymmetry, regardless of any history of depression. Compared to subjects with at least one non-risk allele, subjects with homozygous HTR1A risk alleles had significantly greater relative right frontal activity at sites F7/F8, F5/F6, and F1/F2. In conclusion, variation in HTR1a can influence trait level brain activity, which may ultimately be indicative of risk for psychopathology.

AB - Polymorphic variations in genes related to serotonin synthesis, transport, recognition, or degradation may convey subtle changes in serotonin system architecture that may place an individual at risk for psychopathology when faced with life stressors. The relationship between three key serotonin alleles and frontal brain electrical asymmetry, a putative endophenotype of depression, was examined. Risk alleles were hypothesized to predict relatively greater right frontal brain activity regardless of current clinical state. A sample of 313 college-age individuals, spanning a range of depressive severity from no symptomotology to clinically meaningful levels, participated. Resting encephalographic (EEG) activity was recorded from 64 scalp sites on four occasions separated by at least 24. h (two 8-min recording sessions occurring at each occasion). Alpha power asymmetry scores between homologous sites were calculated for each session and then averaged to form a trait metric of asymmetry for each pair. PCR based genotyping was conducted for the HTR1a, HTR2a, and HTTLPR genes. Variations in the HTR1a gene were related to trait EEG asymmetry, regardless of any history of depression. Compared to subjects with at least one non-risk allele, subjects with homozygous HTR1A risk alleles had significantly greater relative right frontal activity at sites F7/F8, F5/F6, and F1/F2. In conclusion, variation in HTR1a can influence trait level brain activity, which may ultimately be indicative of risk for psychopathology.

KW - Asymmetry

KW - EEG

KW - Endophenotype

KW - Gene

KW - HTR1a

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=75949129620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75949129620&partnerID=8YFLogxK

U2 - 10.1016/j.biopsycho.2009.12.002

DO - 10.1016/j.biopsycho.2009.12.002

M3 - Article

C2 - 20025927

AN - SCOPUS:75949129620

VL - 83

SP - 153

EP - 158

JO - Biological Psychology

JF - Biological Psychology

SN - 0019-493X

IS - 2

ER -