Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES

Linda C. Meade-Tollin, E. M Kithsiri Wijeratne, Deborah Cooper, Mischa Guild, Edlyn Jon, Anne Fritz, Guang Xiong Zhou, Luke Whitesell, Jing Yu Liang, Leslie Gunatilaka

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.

Original languageEnglish (US)
Pages (from-to)2-4
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number1
DOIs
StatePublished - Jan 2004

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Isodon
Isodon (Lamiaceae)
herbal medicines
prostatic neoplasms
angiogenesis
diterpenoids
endothelial cells
dietary supplements
fractionation
Dietary supplements
bioassays
Bioassay
Diterpenes
Endothelial cells
extracts
assays
Fractionation
Dietary Supplements
Biological Assay
Assays

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES. / Meade-Tollin, Linda C.; Wijeratne, E. M Kithsiri; Cooper, Deborah; Guild, Mischa; Jon, Edlyn; Fritz, Anne; Zhou, Guang Xiong; Whitesell, Luke; Liang, Jing Yu; Gunatilaka, Leslie.

In: Journal of Natural Products, Vol. 67, No. 1, 01.2004, p. 2-4.

Research output: Contribution to journalArticle

Meade-Tollin, LC, Wijeratne, EMK, Cooper, D, Guild, M, Jon, E, Fritz, A, Zhou, GX, Whitesell, L, Liang, JY & Gunatilaka, L 2004, 'Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES', Journal of Natural Products, vol. 67, no. 1, pp. 2-4. https://doi.org/10.1021/np0304114
Meade-Tollin, Linda C. ; Wijeratne, E. M Kithsiri ; Cooper, Deborah ; Guild, Mischa ; Jon, Edlyn ; Fritz, Anne ; Zhou, Guang Xiong ; Whitesell, Luke ; Liang, Jing Yu ; Gunatilaka, Leslie. / Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES. In: Journal of Natural Products. 2004 ; Vol. 67, No. 1. pp. 2-4.
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AU - Cooper, Deborah

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AU - Jon, Edlyn

AU - Fritz, Anne

AU - Zhou, Guang Xiong

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AU - Liang, Jing Yu

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