Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES

Linda C. Meade-Tollin, E. M.Kithsiri Wijeratne, Deborah Cooper, Mischa Guild, Edlyn Jon, Anne Fritz, Guang Xiong Zhou, Luke Whitesell, Jing Yu Liang, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.

Original languageEnglish (US)
Pages (from-to)2-4
Number of pages3
JournalJournal Of Natural Products
Volume67
Issue number1
DOIs
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Meade-Tollin, L. C., Wijeratne, E. M. K., Cooper, D., Guild, M., Jon, E., Fritz, A., Zhou, G. X., Whitesell, L., Liang, J. Y., & Gunatilaka, A. A. L. (2004). Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES. Journal Of Natural Products, 67(1), 2-4. https://doi.org/10.1021/np0304114