Poor-prognosis gestational trophoblastic disease

An update

E. A. Surwit, David S Alberts, C. D. Christian, V. E. Graham

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Ten patients with poor-prognosis gestational trophoblastic neoplasia were treated from 1979 to 1983 primarily with the modified Bagshawe chemotherapy regimen. Four patients were noted to have brain metastases, and one patient had liver metastases. In addition, etoposide (VP-16) was used in 7 patients, bleomycin in 6, cisplatin in 5, 5-fluorouracil in 2, and cis-retinoic acid in 4 patients. Thoracotomy, hysterectomy, and splenectomy were performed after chemotherapy was initiated for isolated resistant disease. At present, 9 of the 10 patients (90%) are in complete remission for 4 to 44 months. Significant myelosuppression was encountered in 7 patients and life-threatening toxicity was noted in 2 patients. Currently, poor-prognosis patients are treated with the modified Bagshawe regimen, alternating every other week with etoposide, bleomycin, and cisplatin.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalObstetrics and Gynecology
Volume64
Issue number1
StatePublished - 1984

Fingerprint

Gestational Trophoblastic Disease
Etoposide
NSC 153174
Cisplatin
Neoplasm Metastasis
Drug Therapy
Bleomycin
Splenectomy
Thoracotomy
Tretinoin
Hysterectomy
Fluorouracil

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Surwit, E. A., Alberts, D. S., Christian, C. D., & Graham, V. E. (1984). Poor-prognosis gestational trophoblastic disease: An update. Obstetrics and Gynecology, 64(1), 21-26.

Poor-prognosis gestational trophoblastic disease : An update. / Surwit, E. A.; Alberts, David S; Christian, C. D.; Graham, V. E.

In: Obstetrics and Gynecology, Vol. 64, No. 1, 1984, p. 21-26.

Research output: Contribution to journalArticle

Surwit, EA, Alberts, DS, Christian, CD & Graham, VE 1984, 'Poor-prognosis gestational trophoblastic disease: An update', Obstetrics and Gynecology, vol. 64, no. 1, pp. 21-26.
Surwit, E. A. ; Alberts, David S ; Christian, C. D. ; Graham, V. E. / Poor-prognosis gestational trophoblastic disease : An update. In: Obstetrics and Gynecology. 1984 ; Vol. 64, No. 1. pp. 21-26.
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