Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia

Robert T Dorr, J. Robert Powell, Meredith Heick, David W. Barry

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was treated with trimethoprim/ sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) of the suppository dose absorbed for TMP and SMX were 3 0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained.

Original languageEnglish (US)
Pages (from-to)123-125
Number of pages3
JournalPostgraduate Medical Journal
Volume57
Issue number664
DOIs
StatePublished - 1981

Fingerprint

Sulfamethoxazole
Trimethoprim
Pneumocystis Pneumonia
Suppositories
Sulfamethoxazole Drug Combination Trimethoprim
Treatment Failure
Hodgkin Disease
Tablets
Vomiting
Pharmaceutical Preparations
Rectal Absorption

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

Cite this

Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia. / Dorr, Robert T; Powell, J. Robert; Heick, Meredith; Barry, David W.

In: Postgraduate Medical Journal, Vol. 57, No. 664, 1981, p. 123-125.

Research output: Contribution to journalArticle

Dorr, Robert T ; Powell, J. Robert ; Heick, Meredith ; Barry, David W. / Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia. In: Postgraduate Medical Journal. 1981 ; Vol. 57, No. 664. pp. 123-125.
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