Poor rectal absorption of trimethoprim/sulphamethoxazole in treating Pneumocystis carinii pneumonia

Robert T. Dorr, J. Robert Powell, Meredith Heick, David W. Barry

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A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was treated with trimethoprim/ sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) of the suppository dose absorbed for TMP and SMX were 3 0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained.

Original languageEnglish (US)
Pages (from-to)123-125
Number of pages3
JournalPostgraduate Medical Journal
Issue number664
StatePublished - Jan 1 1981


ASJC Scopus subject areas

  • Medicine(all)

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