Population pharmacokinetics of aminoglycosides in critically ill trauma patients on once-daily regimens

Jeffrey F. Barletta, Steven B. Johnson, David E. Nix, Laura C. Nix, Brian L. Erstad

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Background: Once-daily dosing regimens of aminoglycosides are routinely used in critically ill trauma patients. However, the pharmacokinetic parameters are variable in these patients. The purpose of this study was to evaluate the pharmacokinetics of aminoglycosides in critically ill trauma patients receiving once-daily dosing regimens. Methods: At least two aminoglycoside concentrations were measured in each patient. Population pharmacokinetic parameters were estimated on the basis of a one-compartment structural model and the program nonlinear mixed effects modeling. Results: Fifty-three aminoglycoside concentrations from 19 patients were analyzed. The aminoglycoside clearance was 5.47 L/h. The mean volume of distribution was 22.2 L (0.3 L/kg). The mean half-life was 2.9 hours. Serum-aminoglycoside concentrations were undetectable for longer than 12 hours in 4 of 19 patients. Weight, age, or serum creatinine did not significantly explain the variability. Conclusion: There is marked variability in aminoglycoside pharmacokinetic parameters in critically ill trauma patients. This may lead to prolonged drug-free intervals. Individualized dosing of critically ill trauma patients on the basis of at least two serum-aminoglycoside concentrations seems indicated when using once-daily dosing regimens.

Original languageEnglish (US)
Pages (from-to)869-872
Number of pages4
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume49
Issue number5
DOIs
StatePublished - Jan 1 2000

Keywords

  • Aminoglycosides
  • Dosing
  • Once daily
  • Pharmacokinetics
  • Trauma

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Population pharmacokinetics of aminoglycosides in critically ill trauma patients on once-daily regimens'. Together they form a unique fingerprint.

  • Cite this