Population structure of Y chromosome SNP haplogroups in the United States and forensic implications for constructing Y chromosome STR databases

Michael F Hammer, Veronica F. Chamberlain, Veronica F. Kearney, Daryn Stover, Gina Zhang, Tatiana Karafet, James "Bruce" Walsh, Alan J. Redd

Research output: Contribution to journalArticle

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Abstract

A set of 61 Y chromosome single-nucleotide-polymorphisms (Y-SNPs) is typed in a sample of 2517 individuals from 38 populations to infer the geographic origins of Y chromosomes in the United States and to test for paternal admixture among African-, European-, Hispanic-, Asian-, and Native-Americans. All of the samples were previously typed with the 11 core U.S. Y chromosome short tandem repeats (Y-STRs) recommended by SWGDAM, which revealed high levels of among ethnic group variation and low levels of among-population-within-ethnic-group variation. Admixture estimates vary greatly among populations and ethnic groups. The frequencies of non-European (3.4%) and non-Asian (4.5%) Y chromosomes are generally low in European-American and Asian-American populations, respectively. The frequencies of European Y chromosomes in Native-American populations range widely (i.e., 7-89%) and follow a West to East gradient, whereas they are relatively consistent in African-American populations (26.4 ± 8.9%) from different locations. The European (77.8 ± 9.3%) and Native-American (13.7 ± 7.4%) components of the Hispanic paternal gene pool are also relatively constant among geographic regions; however, the African contribution is much higher in the Northeast (10.5 ± 6.4%) than in the Southwest (1.5 ± 0.9%) or Midwest (0%). To test for the effects of inter-ethnic admixture on the structure of Y-STR diversity in the U.S., we perform subtraction analyses in which Y chromosomes inferred to be admixed by Y-SNP analysis are removed from the database and pairwise population differentiation tests are implemented on the remaining Y-STR haplotypes. Results show that low levels of heterogeneity previously observed between pairs of Hispanic-American populations disappear when African-derived chromosomes are removed from the analysis. This is not the case for an unusual sample of European-Americans from New York City when its African-derived chromosomes are removed, or for Native-American populations when European-derived chromosomes are removed. We infer that both inter-ethnic admixture and population structure in ancestral source populations may contribute to fine scale Y-STR heterogeneity within U.S. ethnic groups.

Original languageEnglish (US)
Pages (from-to)45-55
Number of pages11
JournalForensic Science International
Volume164
Issue number1
DOIs
StatePublished - Dec 1 2006

Fingerprint

Y Chromosome
Chromosomes
Single Nucleotide Polymorphism
Databases
North American Indians
Population
Ethnic Groups
Microsatellite Repeats
Hispanic Americans
Asian Americans
Polymorphism
Gene Pool
Nucleotides
Population Groups
African Americans
Haplotypes
Genes

Keywords

  • Admixture
  • DNA typing
  • Ethnic groups
  • Forensic science
  • Population structure
  • Single nucleotide polymorphisms (SNPs)
  • United States
  • Y chromosome
  • Y-STR databases

ASJC Scopus subject areas

  • Genetics
  • Analytical Chemistry
  • Pathology and Forensic Medicine
  • Psychiatry and Mental health

Cite this

Population structure of Y chromosome SNP haplogroups in the United States and forensic implications for constructing Y chromosome STR databases. / Hammer, Michael F; Chamberlain, Veronica F.; Kearney, Veronica F.; Stover, Daryn; Zhang, Gina; Karafet, Tatiana; Walsh, James "Bruce"; Redd, Alan J.

In: Forensic Science International, Vol. 164, No. 1, 01.12.2006, p. 45-55.

Research output: Contribution to journalArticle

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