Abstract
Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 155-166 |
| Number of pages | 12 |
| Journal | Immunologic Research |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
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Keywords
- Cell surface molecules
- Cellular proliferation
- Co-receptor
- Co-stimulatory molecules
- Signal transduction
ASJC Scopus subject areas
- Immunology
Cite this
Positive and negative roles of CD72 in B cell function. / Wu, Hsin-Jung Joyce; Bondada, Subbarao.
In: Immunologic Research, Vol. 25, No. 2, 2002, p. 155-166.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Positive and negative roles of CD72 in B cell function
AU - Wu, Hsin-Jung Joyce
AU - Bondada, Subbarao
PY - 2002
Y1 - 2002
N2 - Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.
AB - Regulation of B cell activation depends on integration of signals transmitted by the B cell receptor (BCR) and a variety of co-receptors. CD72 is a B cell co-receptor that is expressed in all stages of B cell development except plasma cells. Ligation of CD72 enhances B cell growth and differentiation. Recently, the class IV semaphoring, CD100, has been identified as the natural ligand for CD72. Cytoplasmic domain of CD72 has been shown to be associated with SHP-1 leading to the proposal that the positive effects of CD72 on B cell response may result from sequestration of negative signals from BCR. However, association of CD72 with Grb2 and/or CD19 suggests that CD72 could transmit positive signals. Based on these data, we propose a dual signaling model of CD72.
KW - Cell surface molecules
KW - Cellular proliferation
KW - Co-receptor
KW - Co-stimulatory molecules
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=0036202423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036202423&partnerID=8YFLogxK
U2 - 10.1385/IR:25:2:155
DO - 10.1385/IR:25:2:155
M3 - Article
C2 - 11999169
AN - SCOPUS:0036202423
VL - 25
SP - 155
EP - 166
JO - Immunologic Research
JF - Immunologic Research
SN - 0257-277X
IS - 2
ER -