Possible relationship between chromosome alterations and in vitro cellular radiosensitivity of human malignant melanoma

Heyoung McBride, Baldassarre Stea, Anna Hill, Jeffrey Trent

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the present study, in vitro radiation survival analysis was performed on 8 human malignant melanoma cell lines with defined karyotypes. Exponentially growing cells were irradiated to doses of 0 to 8 Gy and examined for soft agar clonogenicity. Two groups emerged from this analysis: 4 cell lines with a small shoulder (extrapolation number, n < 2) and 4 cell lines with a large shoulder (n > 2). Of possible significance, 4 4 cell lines with extrapolation numbers > 2 demonstrated clonal structural abnormalities of chromosome 7. In contrast, 3 4 cell lines with extrapolation numbers < 2 had no structural abnormalities of chromosome 7. These very preliminary results suggest that structural alterations of chromosome 7 may be associated with melanoma tumors with high extrapolation numbers.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume19
Issue number2
DOIs
StatePublished - 1990

Fingerprint

Radiation Tolerance
chromosomes
radiation tolerance
cultured cells
Chromosomes, Human, Pair 7
extrapolation
Melanoma
Chromosomes
Cell Line
abnormalities
Survival Analysis
shoulders
Karyotype
Agar
tumors
Radiation
dosage
In Vitro Techniques
radiation
cells

Keywords

  • Cytogenetics
  • Malignant melanoma
  • Radiosensitivity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Possible relationship between chromosome alterations and in vitro cellular radiosensitivity of human malignant melanoma. / McBride, Heyoung; Stea, Baldassarre; Hill, Anna; Trent, Jeffrey.

In: International Journal of Radiation Oncology Biology Physics, Vol. 19, No. 2, 1990, p. 349-355.

Research output: Contribution to journalArticle

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