Post-exposure treatment of Ebola virus using passive immunotherapy

Proposal for a new strategy

Jean Philippe Chippaux, Leslie V Boyer, Alejandro Alagón

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa.Methods: We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products.Results: Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics.Conclusion: Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.

Original languageEnglish (US)
Article number3
JournalJournal of Venomous Animals and Toxins Including Tropical Diseases
Volume21
Issue number1
DOIs
StatePublished - Feb 15 2015

Fingerprint

Ebolavirus
Passive Immunization
immunotherapy
Viruses
Ebola Hemorrhagic Fever
Immunoglobulin G
antivenoms
Antivenins
Venoms
systematic review
venoms
Therapeutics
Immunotherapy
Horses
Logistics
manufacturing
Derivatives
horses
Costs and Cost Analysis
Serum

Keywords

  • Africa
  • Ebola
  • Epidemics
  • Immunotherapy
  • Prophylaxis

ASJC Scopus subject areas

  • Toxicology
  • Animal Science and Zoology
  • Infectious Diseases
  • Parasitology

Cite this

Post-exposure treatment of Ebola virus using passive immunotherapy : Proposal for a new strategy. / Chippaux, Jean Philippe; Boyer, Leslie V; Alagón, Alejandro.

In: Journal of Venomous Animals and Toxins Including Tropical Diseases, Vol. 21, No. 1, 3, 15.02.2015.

Research output: Contribution to journalArticle

@article{37196143cba34fd89158ef229839cc80,
title = "Post-exposure treatment of Ebola virus using passive immunotherapy: Proposal for a new strategy",
abstract = "Background: Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa.Methods: We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products.Results: Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics.Conclusion: Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.",
keywords = "Africa, Ebola, Epidemics, Immunotherapy, Prophylaxis",
author = "Chippaux, {Jean Philippe} and Boyer, {Leslie V} and Alejandro Alag{\'o}n",
year = "2015",
month = "2",
day = "15",
doi = "10.1186/s40409-015-0003-1",
language = "English (US)",
volume = "21",
journal = "Journal of Venomous Animals and Toxins Including Tropical Diseases",
issn = "1678-9199",
publisher = "Centro de Estudos de Venenos e Animais Peconhentos",
number = "1",

}

TY - JOUR

T1 - Post-exposure treatment of Ebola virus using passive immunotherapy

T2 - Proposal for a new strategy

AU - Chippaux, Jean Philippe

AU - Boyer, Leslie V

AU - Alagón, Alejandro

PY - 2015/2/15

Y1 - 2015/2/15

N2 - Background: Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa.Methods: We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products.Results: Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics.Conclusion: Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.

AB - Background: Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa.Methods: We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products.Results: Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics.Conclusion: Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.

KW - Africa

KW - Ebola

KW - Epidemics

KW - Immunotherapy

KW - Prophylaxis

UR - http://www.scopus.com/inward/record.url?scp=84927721159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927721159&partnerID=8YFLogxK

U2 - 10.1186/s40409-015-0003-1

DO - 10.1186/s40409-015-0003-1

M3 - Article

VL - 21

JO - Journal of Venomous Animals and Toxins Including Tropical Diseases

JF - Journal of Venomous Animals and Toxins Including Tropical Diseases

SN - 1678-9199

IS - 1

M1 - 3

ER -