Post-exposure treatment of Ebola virus using passive immunotherapy: Proposal for a new strategy

Jean Philippe Chippaux, Leslie V. Boyer, Alejandro Alagón

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Background: Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa.Methods: We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products.Results: Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics.Conclusion: Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.

Original languageEnglish (US)
Article number3
JournalJournal of Venomous Animals and Toxins Including Tropical Diseases
Volume21
Issue number1
DOIs
StatePublished - Feb 15 2015

Keywords

  • Africa
  • Ebola
  • Epidemics
  • Immunotherapy
  • Prophylaxis

ASJC Scopus subject areas

  • Parasitology
  • Animal Science and Zoology
  • Toxicology
  • Infectious Diseases

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