Postoperative Adjuvant Chemotherapy With Fluorouracil, Doxorubicin, Cyclophosphamide, and BCG Vaccine: A Follow-up Report

Aman U. Buzdar, George R. Blumenschein, Charles K. Tashima, Gabriel N. Hortobagyi, Jordan U. Gutterman, Evan M. Hersh, Emil Freireich, Terry L. Smith, Edmund A. Gehan, Luis T. Campos, Warren L. Wheeler

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36 Scopus citations

Abstract

Two hundred twenty-two patients with stage II or III breast cancer following regional therapy were treated with a combination of fluorouracil, doxorubicin hydrochloride (Adriamycin), cyclophosphamide, and BCG vaccine. At 54 months of study (median follow-up, 30 months), the estimated proportions remaining disease-free two and three years after surgery were 83% and 78%, respectively, in the chemotherapy group and 64% and 55%, respectively, in 151 historical control patients. Estimated two- and three-year survival rates were 93% and 89%, respectively, in the chemotherapy group and 84% and 58%, respectively, in the control patients. Congestive heart failure has developed in three patients, possibly related to the use of doxorubicin. Adjuvant chemotherapy with these drugs was effective in prolonging the disease-free interval and survival of patients irrespective of menopausal status, degree of nodal involvement, or stage of the disease. (JAMA 242:1509-1513, 1979).

Original languageEnglish (US)
Pages (from-to)1509-1513
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume242
Issue number14
DOIs
StatePublished - Oct 5 1979

ASJC Scopus subject areas

  • Medicine(all)

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    Buzdar, A. U., Blumenschein, G. R., Tashima, C. K., Hortobagyi, G. N., Gutterman, J. U., Hersh, E. M., Freireich, E., Smith, T. L., Gehan, E. A., Campos, L. T., & Wheeler, W. L. (1979). Postoperative Adjuvant Chemotherapy With Fluorouracil, Doxorubicin, Cyclophosphamide, and BCG Vaccine: A Follow-up Report. JAMA: The Journal of the American Medical Association, 242(14), 1509-1513. https://doi.org/10.1001/jama.1979.03300140025017