Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol

Iga N. Wegorzewska, Katy Walters, Michael J. Weiser, Danette F. Cruthirds, Emily Ewell, Darwin O. Larco, Robert J. Handa, T. John Wu

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.

Original languageEnglish (US)
Pages (from-to)67.e1-67.e5
JournalAmerican journal of obstetrics and gynecology
Volume199
Issue number1
DOIs
StatePublished - Jul 2008
Externally publishedYes

Keywords

  • adrenalectomy
  • body weight
  • menopause
  • ovariectomy
  • rat
  • specific estrogen receptor modulators

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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