Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol

Iga N. Wegorzewska, Katy Walters, Michael J. Weiser, Danette F. Cruthirds, Emily Ewell, Darwin O. Larco, Robert J Handa, T. John Wu

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume199
Issue number1
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Weight Gain
Estrogens
Estrogen Receptors
Body Weight
NAD
Postmenopause
Ovariectomy
Menopause
Estradiol
Animal Models

Keywords

  • adrenalectomy
  • body weight
  • menopause
  • ovariectomy
  • rat
  • specific estrogen receptor modulators

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol. / Wegorzewska, Iga N.; Walters, Katy; Weiser, Michael J.; Cruthirds, Danette F.; Ewell, Emily; Larco, Darwin O.; Handa, Robert J; Wu, T. John.

In: American Journal of Obstetrics and Gynecology, Vol. 199, No. 1, 07.2008.

Research output: Contribution to journalArticle

Wegorzewska, Iga N. ; Walters, Katy ; Weiser, Michael J. ; Cruthirds, Danette F. ; Ewell, Emily ; Larco, Darwin O. ; Handa, Robert J ; Wu, T. John. / Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol. In: American Journal of Obstetrics and Gynecology. 2008 ; Vol. 199, No. 1.
@article{94c57686090c41ad9b3b59720ed89b41,
title = "Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol",
abstract = "Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.",
keywords = "adrenalectomy, body weight, menopause, ovariectomy, rat, specific estrogen receptor modulators",
author = "Wegorzewska, {Iga N.} and Katy Walters and Weiser, {Michael J.} and Cruthirds, {Danette F.} and Emily Ewell and Larco, {Darwin O.} and Handa, {Robert J} and Wu, {T. John}",
year = "2008",
month = "7",
doi = "10.1016/j.ajog.2007.11.054",
language = "English (US)",
volume = "199",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol

AU - Wegorzewska, Iga N.

AU - Walters, Katy

AU - Weiser, Michael J.

AU - Cruthirds, Danette F.

AU - Ewell, Emily

AU - Larco, Darwin O.

AU - Handa, Robert J

AU - Wu, T. John

PY - 2008/7

Y1 - 2008/7

N2 - Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.

AB - Objective: The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause. Study Design: Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized. Results: Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment. Conclusion: These results suggest that the activation of ERα is important in regulating body weight.

KW - adrenalectomy

KW - body weight

KW - menopause

KW - ovariectomy

KW - rat

KW - specific estrogen receptor modulators

UR - http://www.scopus.com/inward/record.url?scp=45649083170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45649083170&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2007.11.054

DO - 10.1016/j.ajog.2007.11.054

M3 - Article

VL - 199

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 1

ER -