Potential applications of imaging and -guided radiotherapy for brain metastases and glioblastoma to improve patient quality of life

Nam P. Nguyen, Mai L. Nguyen, Jacqueline Vock, Claire Lemanski, Christine Kerr, Vincent Vinh-Hung, Alexander Chi, Rihan Khan, William Woods, Gabor Altdorfer, Mark D'Andrea, Ulf Karlsson, Russell J Hamilton, Fred Ampil

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Treatment of glioblastoma multiforme (GBM) and brain metastasis remains a challenge because of the poor survival and the potential for brain damage following radiation. Despite concurrent chemotherapy and radiation dose escalation, local recurrence remains the predominant pattern of failure in GBM most likely secondary to repopulation of cancer stem cells. Even though radiotherapy is highly effective for local control of radio-resistant tumors such as melanoma and renal cell cancer, systemic disease progression is the cause of death in most patients with brain metastasis. Preservation of quality of life (QOL) of cancer survivors is the main issue for patients with brain metastasis. Image-guided radiotherapy (IGRT) by virtue of precise radiation dose delivery may reduce treatment time of patients with GBM without excessive toxicity and potentially improve neurocognitive function with preservation of local control in patients with brain metastasis. Future prospective trials for primary brain tumors or brain metastasis should include IGRT to assess its efficacy to improve patient QOL.

Original languageEnglish (US)
Article number00284
JournalFrontiers in Oncology
Volume3 NOV
DOIs
StatePublished - 2013

Fingerprint

Glioblastoma
Radiotherapy
Quality of Life
Neoplasm Metastasis
Brain
Image-Guided Radiotherapy
Radiation
Neoplastic Stem Cells
Radio
Renal Cell Carcinoma
Brain Neoplasms
Survivors
Disease Progression
Cause of Death
Melanoma
Neoplasms
Recurrence
Drug Therapy
Survival
Therapeutics

Keywords

  • Brain metastases
  • Glioblastoma
  • Image-guided radiotherapy
  • Neurotoxicity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Potential applications of imaging and -guided radiotherapy for brain metastases and glioblastoma to improve patient quality of life. / Nguyen, Nam P.; Nguyen, Mai L.; Vock, Jacqueline; Lemanski, Claire; Kerr, Christine; Vinh-Hung, Vincent; Chi, Alexander; Khan, Rihan; Woods, William; Altdorfer, Gabor; D'Andrea, Mark; Karlsson, Ulf; Hamilton, Russell J; Ampil, Fred.

In: Frontiers in Oncology, Vol. 3 NOV, 00284, 2013.

Research output: Contribution to journalArticle

Nguyen, NP, Nguyen, ML, Vock, J, Lemanski, C, Kerr, C, Vinh-Hung, V, Chi, A, Khan, R, Woods, W, Altdorfer, G, D'Andrea, M, Karlsson, U, Hamilton, RJ & Ampil, F 2013, 'Potential applications of imaging and -guided radiotherapy for brain metastases and glioblastoma to improve patient quality of life', Frontiers in Oncology, vol. 3 NOV, 00284. https://doi.org/10.3389/fonc.2013.00284
Nguyen, Nam P. ; Nguyen, Mai L. ; Vock, Jacqueline ; Lemanski, Claire ; Kerr, Christine ; Vinh-Hung, Vincent ; Chi, Alexander ; Khan, Rihan ; Woods, William ; Altdorfer, Gabor ; D'Andrea, Mark ; Karlsson, Ulf ; Hamilton, Russell J ; Ampil, Fred. / Potential applications of imaging and -guided radiotherapy for brain metastases and glioblastoma to improve patient quality of life. In: Frontiers in Oncology. 2013 ; Vol. 3 NOV.
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