Pre-pregnancy weight and excess weight gain are risk factors for macrosomia in women with gestational diabetes

J. G. Ouzounian, G. D. Hernandez, L. M. Korst, M. M. Montoro, L. R. Battista, C. L. Walden, R. H. Lee

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Objective:To determine whether women with gestational diabetes mellitus (GDM) whose weight gain exceeded the 2009 Institute of Medicine (IOM) recommendations were more likely to have macrosomia.Study Design:Retrospective cohort study of the association of weight gain in women with Class A1 GDM, with term (37 weeks) singleton liveborns and macrosomia (birthweight 4000 g). Multivariate logistic regression models were used to adjust for covariates and test for interactions.Result:Of 1502 women studied, pre-pregnancy body mass index (BMI) categories were: normal (39.6%), overweight (28.5%) and obese (31.9%). The mean (standard deviation) weight gain (lbs) for these groups was: 27.610.9, 24.213.0 and 18.816.3 (P0.0001), whereas the occurrence of macrosomia was 7.4, 11.4 and 19.0%, respectively. Women with an obese BMI were twice as likely to have a macrosomic infant compared with women in the normal BMI group (odds ratio, OR 2.0; 95% CI 1.4-3.0; P0.0005). Independently, women who exceeded the IOM guidelines were three times more likely to have a macrosomic infant (OR 3.0, 95% CI 2.2-4.2, P0.0001).Conclusion:Maternal pre-pregnancy weight and weight gain during pregnancy appear to be significant and independent risk factors for macrosomia in women with GDM.

Original languageEnglish (US)
Pages (from-to)717-721
Number of pages5
JournalJournal of Perinatology
Volume31
Issue number11
DOIs
StatePublished - Nov 2011
Externally publishedYes

Keywords

  • gestational diabetes
  • macrosomia
  • obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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