Prediction of Setschenow constants

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Abstract

The Setschenow (salting out) constant by sodium chloride is related to molar volume, aqueous solubility, and octanol-water partition coefficient, Kow, of the drug solute. This study validates a previously proposed relationship between the salting out constant of a solute and its partition coefficient. It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume254
Issue number2
DOIs
Publication statusPublished - Mar 26 2003

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Keywords

  • Intrinsic solubility
  • Le Bas volume
  • Partition coefficient
  • Setschenow constant

ASJC Scopus subject areas

  • Pharmaceutical Science

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