Prediction of Setschenow constants

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The Setschenow (salting out) constant by sodium chloride is related to molar volume, aqueous solubility, and octanol-water partition coefficient, Kow, of the drug solute. This study validates a previously proposed relationship between the salting out constant of a solute and its partition coefficient. It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume254
Issue number2
DOIs
StatePublished - Mar 26 2003

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Solubility
Octanols
Sodium Chloride
Water
Pharmaceutical Preparations

Keywords

  • Intrinsic solubility
  • Le Bas volume
  • Partition coefficient
  • Setschenow constant

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Prediction of Setschenow constants. / Ni, Nina; Yalkowsky, Samuel H.

In: International Journal of Pharmaceutics, Vol. 254, No. 2, 26.03.2003, p. 167-172.

Research output: Contribution to journalArticle

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