Predictors of graft patency 3 years after coronary artery bypass graft surgery

Steven Goldman, Karen Zadina, Barbara Krasnicka, Thomas Moritz, Gulshan Sethi, Jack Copeland, Theron Ovitt, William Henderson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objectives. The purpose of this analysis was to define the factors that predict 3-year graft patency. Background. The success of coronary artery bypass graft surgery (CABG) is dependent on vein graft patency after the operation. It has been well established by a series of Department of Veterans Affairs Cooperative Trials that aspirin (325 mg daily) improves saphenous vein graft patency early (7 to 10 days) and at 1 year, but not at 3 years after CABG. This analysis, based on one of these trials, defined factors that predict 3-year graft patency. Methods. This analysis consisted of 266 patients, with 656 grafts that were patent 7 to 10 days after the operation, who underwent 3-year catheterization. To determine which patient-specific and/or graft-specific factors, or both, predict graft occlusion, a multivariate logistic regression analysis in terms of latent variables was used. It yielded a model that also took into account possible intraclass correlations. Results. For a vein graft that was patent at 7 to 10 days after the operation, the positive predictors, according to univariate analysis, for that being patent at 3 years were cross-clamp time ≤80 min (p < 0.001), vein preservation solution temperature ≤5°C (p = 0.009), bypass time ≤2 h (p = 0.042), number of proximal anastomoses ≤2 (p = 0.018), operation time ≤5 h (p = 0.044) and continuous versus intermittent cross-clamp technique (p = 0.024). There was also a trend with regard to recipient artery diameter >1.5 mm (p = 0.063), serum cholesterol ≤225 mg/dl (p = 0.084) and single versus sequential or Y vein graft (p = 0.060). Factors not predictive of 3 year patency were age, race, smoking history, high density lipoprotein cholesterol, vein source (thigh vs. calf), coronary artery grafted and aspirin treatment. Of all the predictors obtained in the univariate analysis, the only variables that were sufficient to yield a good model within the multivariate analysis were solution temperature (p = 0.004), serum cholesterol (p = 0.024), number of proximal anastomoses (p = 0.032) and recipient artery diameter (p = 0.034). Conclusions. For a patient with patent vein grafts 7 to 10 days after the operation, predictors of 3-year graft patency are more closely related to operative technique and underlying disease and not to aspirin treatment.

Original languageEnglish (US)
Pages (from-to)1563-1568
Number of pages6
JournalJournal of the American College of Cardiology
Volume29
Issue number7
DOIs
StatePublished - Jun 1997

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Coronary Artery Bypass
Transplants
Veins
Aspirin
Cholesterol
Saphenous Vein
Veterans
Thigh
Serum
Catheterization
HDL Cholesterol
Coronary Vessels
Multivariate Analysis
Arteries
Logistic Models
Smoking
History
Regression Analysis

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Predictors of graft patency 3 years after coronary artery bypass graft surgery. / Goldman, Steven; Zadina, Karen; Krasnicka, Barbara; Moritz, Thomas; Sethi, Gulshan; Copeland, Jack; Ovitt, Theron; Henderson, William.

In: Journal of the American College of Cardiology, Vol. 29, No. 7, 06.1997, p. 1563-1568.

Research output: Contribution to journalArticle

Goldman, S, Zadina, K, Krasnicka, B, Moritz, T, Sethi, G, Copeland, J, Ovitt, T & Henderson, W 1997, 'Predictors of graft patency 3 years after coronary artery bypass graft surgery', Journal of the American College of Cardiology, vol. 29, no. 7, pp. 1563-1568. https://doi.org/10.1016/S0735-1097(97)82539-9
Goldman, Steven ; Zadina, Karen ; Krasnicka, Barbara ; Moritz, Thomas ; Sethi, Gulshan ; Copeland, Jack ; Ovitt, Theron ; Henderson, William. / Predictors of graft patency 3 years after coronary artery bypass graft surgery. In: Journal of the American College of Cardiology. 1997 ; Vol. 29, No. 7. pp. 1563-1568.
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abstract = "Objectives. The purpose of this analysis was to define the factors that predict 3-year graft patency. Background. The success of coronary artery bypass graft surgery (CABG) is dependent on vein graft patency after the operation. It has been well established by a series of Department of Veterans Affairs Cooperative Trials that aspirin (325 mg daily) improves saphenous vein graft patency early (7 to 10 days) and at 1 year, but not at 3 years after CABG. This analysis, based on one of these trials, defined factors that predict 3-year graft patency. Methods. This analysis consisted of 266 patients, with 656 grafts that were patent 7 to 10 days after the operation, who underwent 3-year catheterization. To determine which patient-specific and/or graft-specific factors, or both, predict graft occlusion, a multivariate logistic regression analysis in terms of latent variables was used. It yielded a model that also took into account possible intraclass correlations. Results. For a vein graft that was patent at 7 to 10 days after the operation, the positive predictors, according to univariate analysis, for that being patent at 3 years were cross-clamp time ≤80 min (p < 0.001), vein preservation solution temperature ≤5°C (p = 0.009), bypass time ≤2 h (p = 0.042), number of proximal anastomoses ≤2 (p = 0.018), operation time ≤5 h (p = 0.044) and continuous versus intermittent cross-clamp technique (p = 0.024). There was also a trend with regard to recipient artery diameter >1.5 mm (p = 0.063), serum cholesterol ≤225 mg/dl (p = 0.084) and single versus sequential or Y vein graft (p = 0.060). Factors not predictive of 3 year patency were age, race, smoking history, high density lipoprotein cholesterol, vein source (thigh vs. calf), coronary artery grafted and aspirin treatment. Of all the predictors obtained in the univariate analysis, the only variables that were sufficient to yield a good model within the multivariate analysis were solution temperature (p = 0.004), serum cholesterol (p = 0.024), number of proximal anastomoses (p = 0.032) and recipient artery diameter (p = 0.034). Conclusions. For a patient with patent vein grafts 7 to 10 days after the operation, predictors of 3-year graft patency are more closely related to operative technique and underlying disease and not to aspirin treatment.",
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T1 - Predictors of graft patency 3 years after coronary artery bypass graft surgery

AU - Goldman, Steven

AU - Zadina, Karen

AU - Krasnicka, Barbara

AU - Moritz, Thomas

AU - Sethi, Gulshan

AU - Copeland, Jack

AU - Ovitt, Theron

AU - Henderson, William

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N2 - Objectives. The purpose of this analysis was to define the factors that predict 3-year graft patency. Background. The success of coronary artery bypass graft surgery (CABG) is dependent on vein graft patency after the operation. It has been well established by a series of Department of Veterans Affairs Cooperative Trials that aspirin (325 mg daily) improves saphenous vein graft patency early (7 to 10 days) and at 1 year, but not at 3 years after CABG. This analysis, based on one of these trials, defined factors that predict 3-year graft patency. Methods. This analysis consisted of 266 patients, with 656 grafts that were patent 7 to 10 days after the operation, who underwent 3-year catheterization. To determine which patient-specific and/or graft-specific factors, or both, predict graft occlusion, a multivariate logistic regression analysis in terms of latent variables was used. It yielded a model that also took into account possible intraclass correlations. Results. For a vein graft that was patent at 7 to 10 days after the operation, the positive predictors, according to univariate analysis, for that being patent at 3 years were cross-clamp time ≤80 min (p < 0.001), vein preservation solution temperature ≤5°C (p = 0.009), bypass time ≤2 h (p = 0.042), number of proximal anastomoses ≤2 (p = 0.018), operation time ≤5 h (p = 0.044) and continuous versus intermittent cross-clamp technique (p = 0.024). There was also a trend with regard to recipient artery diameter >1.5 mm (p = 0.063), serum cholesterol ≤225 mg/dl (p = 0.084) and single versus sequential or Y vein graft (p = 0.060). Factors not predictive of 3 year patency were age, race, smoking history, high density lipoprotein cholesterol, vein source (thigh vs. calf), coronary artery grafted and aspirin treatment. Of all the predictors obtained in the univariate analysis, the only variables that were sufficient to yield a good model within the multivariate analysis were solution temperature (p = 0.004), serum cholesterol (p = 0.024), number of proximal anastomoses (p = 0.032) and recipient artery diameter (p = 0.034). Conclusions. For a patient with patent vein grafts 7 to 10 days after the operation, predictors of 3-year graft patency are more closely related to operative technique and underlying disease and not to aspirin treatment.

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