Predictors of microbial agents in dust and respiratory health in the Ecrhs

Christina Tischer, Jan Paul Zock, Maria Valkonen, Gert Doekes, Stefano Guerra, Dick Heederik, Deborah Jarvis, Dan Norbäck, Mario Olivieri, Jordi Sunyer, Cecilie Svanes, Martin Täubel, Elisabeth Thiering, Giuseppe Verlato, Anne Hyvärinen, Joachim Heinrich

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health. Methods: Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively. Results: Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95%CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function. Conclusion: Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.

Original languageEnglish (US)
Article number48
JournalBMC Pulmonary Medicine
Volume15
Issue number1
DOIs
StatePublished - May 2 2015

Fingerprint

Dust
Asthma
Fungi
Health
Lung
Muramic Acids
Fungal Structures
Pets
Linear Models
Interviews
Population

Keywords

  • Airways
  • Asthma
  • Fungi
  • Indoor Air
  • Microbials
  • Molds

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Tischer, C., Zock, J. P., Valkonen, M., Doekes, G., Guerra, S., Heederik, D., ... Heinrich, J. (2015). Predictors of microbial agents in dust and respiratory health in the Ecrhs. BMC Pulmonary Medicine, 15(1), [48]. https://doi.org/10.1186/s12890-015-0042-y

Predictors of microbial agents in dust and respiratory health in the Ecrhs. / Tischer, Christina; Zock, Jan Paul; Valkonen, Maria; Doekes, Gert; Guerra, Stefano; Heederik, Dick; Jarvis, Deborah; Norbäck, Dan; Olivieri, Mario; Sunyer, Jordi; Svanes, Cecilie; Täubel, Martin; Thiering, Elisabeth; Verlato, Giuseppe; Hyvärinen, Anne; Heinrich, Joachim.

In: BMC Pulmonary Medicine, Vol. 15, No. 1, 48, 02.05.2015.

Research output: Contribution to journalArticle

Tischer, C, Zock, JP, Valkonen, M, Doekes, G, Guerra, S, Heederik, D, Jarvis, D, Norbäck, D, Olivieri, M, Sunyer, J, Svanes, C, Täubel, M, Thiering, E, Verlato, G, Hyvärinen, A & Heinrich, J 2015, 'Predictors of microbial agents in dust and respiratory health in the Ecrhs', BMC Pulmonary Medicine, vol. 15, no. 1, 48. https://doi.org/10.1186/s12890-015-0042-y
Tischer, Christina ; Zock, Jan Paul ; Valkonen, Maria ; Doekes, Gert ; Guerra, Stefano ; Heederik, Dick ; Jarvis, Deborah ; Norbäck, Dan ; Olivieri, Mario ; Sunyer, Jordi ; Svanes, Cecilie ; Täubel, Martin ; Thiering, Elisabeth ; Verlato, Giuseppe ; Hyvärinen, Anne ; Heinrich, Joachim. / Predictors of microbial agents in dust and respiratory health in the Ecrhs. In: BMC Pulmonary Medicine. 2015 ; Vol. 15, No. 1.
@article{285d288cfa3c46a49c2787408f4c2497,
title = "Predictors of microbial agents in dust and respiratory health in the Ecrhs",
abstract = "Background: Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health. Methods: Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively. Results: Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95{\%}CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function. Conclusion: Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.",
keywords = "Airways, Asthma, Fungi, Indoor Air, Microbials, Molds",
author = "Christina Tischer and Zock, {Jan Paul} and Maria Valkonen and Gert Doekes and Stefano Guerra and Dick Heederik and Deborah Jarvis and Dan Norb{\"a}ck and Mario Olivieri and Jordi Sunyer and Cecilie Svanes and Martin T{\"a}ubel and Elisabeth Thiering and Giuseppe Verlato and Anne Hyv{\"a}rinen and Joachim Heinrich",
year = "2015",
month = "5",
day = "2",
doi = "10.1186/s12890-015-0042-y",
language = "English (US)",
volume = "15",
journal = "BMC Pulmonary Medicine",
issn = "1471-2466",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Predictors of microbial agents in dust and respiratory health in the Ecrhs

AU - Tischer, Christina

AU - Zock, Jan Paul

AU - Valkonen, Maria

AU - Doekes, Gert

AU - Guerra, Stefano

AU - Heederik, Dick

AU - Jarvis, Deborah

AU - Norbäck, Dan

AU - Olivieri, Mario

AU - Sunyer, Jordi

AU - Svanes, Cecilie

AU - Täubel, Martin

AU - Thiering, Elisabeth

AU - Verlato, Giuseppe

AU - Hyvärinen, Anne

AU - Heinrich, Joachim

PY - 2015/5/2

Y1 - 2015/5/2

N2 - Background: Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health. Methods: Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively. Results: Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95%CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function. Conclusion: Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.

AB - Background: Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health. Methods: Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively. Results: Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95%CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function. Conclusion: Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.

KW - Airways

KW - Asthma

KW - Fungi

KW - Indoor Air

KW - Microbials

KW - Molds

UR - http://www.scopus.com/inward/record.url?scp=84928995476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928995476&partnerID=8YFLogxK

U2 - 10.1186/s12890-015-0042-y

DO - 10.1186/s12890-015-0042-y

M3 - Article

C2 - 25929252

AN - SCOPUS:84928995476

VL - 15

JO - BMC Pulmonary Medicine

JF - BMC Pulmonary Medicine

SN - 1471-2466

IS - 1

M1 - 48

ER -