Predictors of mortality in presenile and senile dementia

Alfred W Kaszniak, J. Fox, D. L. Gandell, D. C. Garron, M. S. Huckman, R. G. Ramsey

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Forty-seven hospitalized patients with a diagnosis of presenile or senile dementia and without focal neurological disease or major systemic illness were given complete neurological, neuroradiological, and neuropsychological examinations. Mortality at one year after hospitalization was determined, 12 patients being lost to follow-up. Of the remaining 35 patients, 19 were alive and 16 had died. These two groups did not differ in age, education, length of dementia history, sex, race, or degree of cerebral atrophy (by computerized tomography). Significant differences were found in degree of electroencephalographic abnormality and in 8 of 14 cognitive measures, the largest single difference being on a test of expressive language. Discriminant function analysis made with the cognitive measures as dependent variables yielded a correct prediction (classification analysis) of mortality in all but 1 case (97% accuracy). These results suggest that (1) degree of functional brain impairment rather than the degree of cerebral atrophy may be the more important influence on mortality in dementia patients without focal lesions, (2) short-term survival may be accurately predicted in such patients by tests of cognitive functioning, and (3) expressive language deficit in such patients may indicate a particularly poor prognosis for survival.

Original languageEnglish (US)
Pages (from-to)246-252
Number of pages7
JournalAnnals of Neurology
Volume3
Issue number3
StatePublished - 1978
Externally publishedYes

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Mortality
Atrophy
Dementia
Language Tests
Survival
Lost to Follow-Up
Discriminant Analysis
Presenile And Senile Dementia
Hospitalization
Language
Tomography
Education
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kaszniak, A. W., Fox, J., Gandell, D. L., Garron, D. C., Huckman, M. S., & Ramsey, R. G. (1978). Predictors of mortality in presenile and senile dementia. Annals of Neurology, 3(3), 246-252.

Predictors of mortality in presenile and senile dementia. / Kaszniak, Alfred W; Fox, J.; Gandell, D. L.; Garron, D. C.; Huckman, M. S.; Ramsey, R. G.

In: Annals of Neurology, Vol. 3, No. 3, 1978, p. 246-252.

Research output: Contribution to journalArticle

Kaszniak, AW, Fox, J, Gandell, DL, Garron, DC, Huckman, MS & Ramsey, RG 1978, 'Predictors of mortality in presenile and senile dementia', Annals of Neurology, vol. 3, no. 3, pp. 246-252.
Kaszniak AW, Fox J, Gandell DL, Garron DC, Huckman MS, Ramsey RG. Predictors of mortality in presenile and senile dementia. Annals of Neurology. 1978;3(3):246-252.
Kaszniak, Alfred W ; Fox, J. ; Gandell, D. L. ; Garron, D. C. ; Huckman, M. S. ; Ramsey, R. G. / Predictors of mortality in presenile and senile dementia. In: Annals of Neurology. 1978 ; Vol. 3, No. 3. pp. 246-252.
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