Predominance of chromosome 5 deletions in myeloid neoplasia associated with solid tumors managed by surgical excision

Alan F. List, Glenn J. Shamdas, Iris Veomett, Catherine S Perry, Rodman Morgan, Avery A. Sandberg

Research output: Contribution to journalArticle

Abstract

To assess potential differences in genetic predisposition to myeloid neoplasia, we evaluated the karyotypes and reviewed results of cytogenetic studies on bone marrow specimens from six patients with myelodysplastic syndrome, or acute myeloid leukemia, and a history of solid tumor managed solely by surgical resection. Structural or numerical deletions of chromosome 5 were identified in each of four patients with abnormal marrow karyotypes. Constitutional karyotypes were normal in two patients studied with clonal marrow chromosome abnormalities. Review of previously reported cases of myeloid neoplasia following resection of solid tumors disclosed a preponderance of chromosome 5 deletions. Predisposition to specific chromosome loss may influence genetic expression of disease in solid tumor patients developing hematologic malignancy.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume58
Issue number2
DOIs
StatePublished - 1992

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Chromosome Deletion
Chromosomes, Human, Pair 5
Bone Marrow
Neoplasms
Karyotype
Abnormal Karyotype
Inborn Genetic Diseases
Myelodysplastic Syndromes
Hematologic Neoplasms
Genetic Predisposition to Disease
Acute Myeloid Leukemia
Cytogenetics
Chromosome Aberrations
Chromosomes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Predominance of chromosome 5 deletions in myeloid neoplasia associated with solid tumors managed by surgical excision. / List, Alan F.; Shamdas, Glenn J.; Veomett, Iris; Perry, Catherine S; Morgan, Rodman; Sandberg, Avery A.

In: Cancer Genetics and Cytogenetics, Vol. 58, No. 2, 1992, p. 125-129.

Research output: Contribution to journalArticle

List, Alan F. ; Shamdas, Glenn J. ; Veomett, Iris ; Perry, Catherine S ; Morgan, Rodman ; Sandberg, Avery A. / Predominance of chromosome 5 deletions in myeloid neoplasia associated with solid tumors managed by surgical excision. In: Cancer Genetics and Cytogenetics. 1992 ; Vol. 58, No. 2. pp. 125-129.
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