Predominance of chromosome 5 deletions in myeloid neoplasia associated with solid tumors managed by surgical excision

Alan F. List, Glenn J. Shamdas, Iris Veomett, Catherine Spier, Rodman Morgan, Avery A. Sandberg

Research output: Contribution to journalArticle

Abstract

To assess potential differences in genetic predisposition to myeloid neoplasia, we evaluated the karyotypes and reviewed results of cytogenetic studies on bone marrow specimens from six patients with myelodysplastic syndrome, or acute myeloid leukemia, and a history of solid tumor managed solely by surgical resection. Structural or numerical deletions of chromosome 5 were identified in each of four patients with abnormal marrow karyotypes. Constitutional karyotypes were normal in two patients studied with clonal marrow chromosome abnormalities. Review of previously reported cases of myeloid neoplasia following resection of solid tumors disclosed a preponderance of chromosome 5 deletions. Predisposition to specific chromosome loss may influence genetic expression of disease in solid tumor patients developing hematologic malignancy.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume58
Issue number2
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Predominance of chromosome 5 deletions in myeloid neoplasia associated with solid tumors managed by surgical excision'. Together they form a unique fingerprint.

  • Cite this