Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology

Eynav E. Accortt; Jennifer L. Stewart; James A. Coan; Rachel Manber; John J.B. Allen

doi:10.1016/j.jad.2010.07.017

Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology

Eynav E. Accortt, Jennifer L. Stewart, James A. Coan, Rachel Manber, John J.B. Allen

Psychology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.

Original language	English (US)
Pages (from-to)	178-183
Number of pages	6
Journal	Journal of Affective Disorders
Volume	128
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jad.2010.07.017
State	Published - Jan 1 2011

Keywords

Diathesis
EEG asymmetry
Pre-menstrual dysphoria
Risk

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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title = "Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology",

abstract = "Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.",

keywords = "Diathesis, EEG asymmetry, Pre-menstrual dysphoria, Risk",

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AU - Stewart, Jennifer L.

AU - Coan, James A.

AU - Manber, Rachel

AU - Allen, John J.B.

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