Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology

Eynav E. Accortt, Jennifer L. Stewart, James A. Coan, Rachel Manber, John JB Allen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.

Original languageEnglish (US)
Pages (from-to)178-183
Number of pages6
JournalJournal of Affective Disorders
Volume128
Issue number1-2
DOIs
StatePublished - Jan 2011

Fingerprint

Major Depressive Disorder
Brain
Disease Susceptibility
Diagnostic and Statistical Manual of Mental Disorders

Keywords

  • Diathesis
  • EEG asymmetry
  • Pre-menstrual dysphoria
  • Risk

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology. / Accortt, Eynav E.; Stewart, Jennifer L.; Coan, James A.; Manber, Rachel; Allen, John JB.

In: Journal of Affective Disorders, Vol. 128, No. 1-2, 01.2011, p. 178-183.

Research output: Contribution to journalArticle

Accortt, Eynav E. ; Stewart, Jennifer L. ; Coan, James A. ; Manber, Rachel ; Allen, John JB. / Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology. In: Journal of Affective Disorders. 2011 ; Vol. 128, No. 1-2. pp. 178-183.
@article{e9cb4c68004f482abbf7caddab98a2cd,
title = "Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology",
abstract = "Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.",
keywords = "Diathesis, EEG asymmetry, Pre-menstrual dysphoria, Risk",
author = "Accortt, {Eynav E.} and Stewart, {Jennifer L.} and Coan, {James A.} and Rachel Manber and Allen, {John JB}",
year = "2011",
month = "1",
doi = "10.1016/j.jad.2010.07.017",
language = "English (US)",
volume = "128",
pages = "178--183",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology

AU - Accortt, Eynav E.

AU - Stewart, Jennifer L.

AU - Coan, James A.

AU - Manber, Rachel

AU - Allen, John JB

PY - 2011/1

Y1 - 2011/1

N2 - Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.

AB - Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.

KW - Diathesis

KW - EEG asymmetry

KW - Pre-menstrual dysphoria

KW - Risk

UR - http://www.scopus.com/inward/record.url?scp=78649661557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649661557&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2010.07.017

DO - 10.1016/j.jad.2010.07.017

M3 - Article

C2 - 20833433

AN - SCOPUS:78649661557

VL - 128

SP - 178

EP - 183

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-2

ER -