TY - JOUR
T1 - Prefrontal brain asymmetry and pre-menstrual dysphoric disorder symptomatology
AU - Accortt, Eynav E.
AU - Stewart, Jennifer L.
AU - Coan, James A.
AU - Manber, Rachel
AU - Allen, John J.B.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.
AB - Background: Pre-menstrual dysphoric disorder (PMDD), a dysphoric form of pre-menstrual syndrome, is included as a diagnosis for further study in the DSM-IV-TR (APA, 2000). The present study investigated whether a marker of risk for major depressive disorder (MDD), prefrontal brain asymmetry, also characterizes women with PMDD. Methods: In a sample of 25 college women with PMDD symptomatology and 25 matched controls, resting frontal electroencephalographic (EEG) activity was assessed on four occasions within a two-week span. Results: Across several frontal sites women with PMDD had relatively less left than right prefrontal brain activity, consistent with a diathesis-stress model for menstrual-related dysphoria. Conclusions: The findings suggest an overlap in the risk profile for MDD and PMDD.
KW - Diathesis
KW - EEG asymmetry
KW - Pre-menstrual dysphoria
KW - Risk
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U2 - 10.1016/j.jad.2010.07.017
DO - 10.1016/j.jad.2010.07.017
M3 - Article
C2 - 20833433
AN - SCOPUS:78649661557
VL - 128
SP - 178
EP - 183
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-2
ER -