Preliminary evaluation of laser-induced breakdown spectroscopy for tissue classification

Fang Yu Yueh, Hongbo Zheng, Jagdish P. Singh, Shane Burgess

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Laser-induced breakdown spectroscopy (LIBS) is an on-line, real-time technology that can produce immediate information about the elemental contents of tissue samples. We have previously shown that LIBS may be used to distinguish cancerous from non-cancerous tissue. In this work, we study LIBS spectra produced from chicken brain, lung, spleen, liver, kidney and skeletal muscle. Different data processing techniques were used to study if the information contained in these LIBS spectra is able to differentiate between different types of tissue samples and then identify unknown tissues. We have demonstrated a clear distinguishing between each of the known tissue types with only 21 selected analyte lines from each observed LIBS spectrum. We found that in order to produce an analytical model to work well with new sample we need to have representative training data to cover a wide range of spectral variation due to experimental or environmental changes.

Original languageEnglish (US)
Pages (from-to)1059-1067
Number of pages9
JournalSpectrochimica Acta - Part B Atomic Spectroscopy
Volume64
Issue number10
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Keywords

  • ANN
  • HCA
  • LIBS
  • PLS
  • Tissue characterization

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Spectroscopy

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