Preliminary experience with synchronized coronary sinus retroperfusion in humans

J. M. Gore, B. H. Weiner, J. R. Benotti, K. M. Sloan, O. N. Okike, H. F. Cuénoud, J. M. Gaca, Joseph S Alpert, J. E. Dalen

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Synchronized coronary sinus retroperfusion (SCSR) with arterial blood has been extensively tested in animals. This intervention offers temporary support to areas of ischemic myocardium while a method of definitive revascularization is being sought. The feasibility and safety of this procedure for patients with unstable angina was therefore tested. A No. 7F autoinflatable retroperfusion balloon catheter (USCI) was inserted into the coronary sinus of the study patients. Arterial blood was obtained through a No. 8F catheter placed in the femoral artery. Arterial blood was infused in a retrograde fashion into the coronary venous system during cardiac diastole by means of a piston-driven pump that was electrocardiographically synchronized with the drainage of the venous system during systole. This procedure was performed in five patients with unstable angina refractory to maximum medical therapy. SCSR significantly decreased the frequency of anginal episodes and the requirement for antianginal medications. SCSR also provided time for patient stabilization before diagnostic cardiac catheterization or therapeutic intervention. This preliminary experience suggests that synchronized coronary sinus retroperfusion is a feasible and safe procedure. It can be performed at the bedside with no apparent adverse effects to the patient. Retroperfusion also appears to be effective in relieving ischemic symptoms as assessed by clinical parameters. Based on our preliminary experience, further delineation of its clinical applications is warranted.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalCirculation
Volume74
Issue number2
StatePublished - 1986
Externally publishedYes

Fingerprint

Coronary Sinus
Unstable Angina
Catheters
Diastole
Systole
Femoral Artery
Patient Safety
Cardiac Catheterization
Drainage
Myocardium
Therapeutics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Gore, J. M., Weiner, B. H., Benotti, J. R., Sloan, K. M., Okike, O. N., Cuénoud, H. F., ... Dalen, J. E. (1986). Preliminary experience with synchronized coronary sinus retroperfusion in humans. Circulation, 74(2), 381-388.

Preliminary experience with synchronized coronary sinus retroperfusion in humans. / Gore, J. M.; Weiner, B. H.; Benotti, J. R.; Sloan, K. M.; Okike, O. N.; Cuénoud, H. F.; Gaca, J. M.; Alpert, Joseph S; Dalen, J. E.

In: Circulation, Vol. 74, No. 2, 1986, p. 381-388.

Research output: Contribution to journalArticle

Gore, JM, Weiner, BH, Benotti, JR, Sloan, KM, Okike, ON, Cuénoud, HF, Gaca, JM, Alpert, JS & Dalen, JE 1986, 'Preliminary experience with synchronized coronary sinus retroperfusion in humans', Circulation, vol. 74, no. 2, pp. 381-388.
Gore JM, Weiner BH, Benotti JR, Sloan KM, Okike ON, Cuénoud HF et al. Preliminary experience with synchronized coronary sinus retroperfusion in humans. Circulation. 1986;74(2):381-388.
Gore, J. M. ; Weiner, B. H. ; Benotti, J. R. ; Sloan, K. M. ; Okike, O. N. ; Cuénoud, H. F. ; Gaca, J. M. ; Alpert, Joseph S ; Dalen, J. E. / Preliminary experience with synchronized coronary sinus retroperfusion in humans. In: Circulation. 1986 ; Vol. 74, No. 2. pp. 381-388.
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