Preliminary Investigation of Multiplexed Pinholes with Circular Apertures and Elliptical Ports for I-123 DAT Imaging

Arda Konik, Timothy Fromme, Jan De Beenhouwer, Yulun He, Soumyanil Banerjee, Kesava Kalluri, Lars R. Furenlid, Michael A. King

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Earlier, we proposed an inexpensive method to improve the performance of the conventional dual-head SPECT systems for I-123 dopamine transporter (DAT) imaging of Parkinson Disease. In this approach, the collimator on one head is replaced with a multi-pinhole (MPH) collimator while retaining the conventional collimator on the other head, thus enabling combined MPH/Parallelbeam (or Fanbeam) acquisition. The original MPH design consisted of 9 apertures with rectangular entrance/exit ports covering a cylindrical volume of interest (VOI) around the striatum with minimal multiplexing. Our main goal in this work is to increase the sensitivity of this system by adding more pinholes and allowing multiplexing. For a more efficient usage of the available detector coverage, we also proposed the usage of pinholes with circular apertures and elliptical ports referred to as 'lofthole' herein. Circular apertures are desired because of the uniform spatial resolution, more accurate point spread function modeling and fabrication while the elliptical ports provide more flexibility in the detector coverage compared to circular ports. In this preliminary work, we present a comparison of 9, 13, 17 and 16 pinhole configurations for conic-holes (circle bases) and loftholes (circular and elliptic bases) through projections obtained from GATE Monte Carlo software.

Original languageEnglish (US)
Title of host publication2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538622827
DOIs
StatePublished - Nov 12 2018
Event2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Atlanta, United States
Duration: Oct 21 2017Oct 28 2017

Other

Other2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017
CountryUnited States
CityAtlanta
Period10/21/1710/28/17

ASJC Scopus subject areas

  • Instrumentation
  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

Fingerprint Dive into the research topics of 'Preliminary Investigation of Multiplexed Pinholes with Circular Apertures and Elliptical Ports for I-123 DAT Imaging'. Together they form a unique fingerprint.

  • Cite this

    Konik, A., Fromme, T., Beenhouwer, J. D., He, Y., Banerjee, S., Kalluri, K., Furenlid, L. R., & King, M. A. (2018). Preliminary Investigation of Multiplexed Pinholes with Circular Apertures and Elliptical Ports for I-123 DAT Imaging. In 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings [8532608] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2017.8532608