Preliminary Investigation to Improve Point Spread Function Modeling for a Multi-Pinhole SPECT Camera

Soumyanil Banerjee, Arda Konik, Joyeeta M. Mukherjee, Kesava S. Kalluri, Justin C. Goding, Luca Caucci, George I. Zubal, Lars R Furenlid, Michael A. King

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Herein we report on the mathematical modeling of the simulated point spread functions (PSFs) of pinhole apertures for clinical I-123 DaTscan imaging on a dual-head SPECT system consisting of fan and multi-pinhole (MPH) collimators on separate heads. The PSFs can be measured sparsely by translating a point source within the volume of interest (VOI). These PSFs were generated using GATE Monte Carlo simulation software and were then modeled using standard 2D Gaussian having 6 parameters, and three other models using higher order polynomial terms as well as cross terms in the exponential. The goal is to efficiently store the parameters of the modeled PSF, measured across the VOI and then interpolate them on the fly during reconstruction. It has been shown that MPH reconstruction can be improved with accurate modeling of the PSF. However, for our application it has been determined that improved accuracy in PSF modeling (reduced NRMSE) can be obtained by incorporating more polynomial terms in the exponential than employed by the standard 2D Gaussian, especially with increased pinhole angulations. In this paper we introduce higher order polynomial terms (degree 3 and 4) as an extension to the Gaussian model and observe that these added terms could significantly reduce the NRMSE.

Original languageEnglish (US)
Title of host publication2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538622827
DOIs
Publication statusPublished - Nov 12 2018
Event2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Atlanta, United States
Duration: Oct 21 2017Oct 28 2017

Other

Other2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017
CountryUnited States
CityAtlanta
Period10/21/1710/28/17

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Keywords

  • -SPECT
  • DaTscan
  • Gaussian
  • Gaussian CC4.
  • GaussianC
  • GaussianCC
  • Multi-pinhole (MPH)
  • Point Spread Function (PSF)

ASJC Scopus subject areas

  • Instrumentation
  • Radiology Nuclear Medicine and imaging
  • Nuclear and High Energy Physics

Cite this

Banerjee, S., Konik, A., Mukherjee, J. M., Kalluri, K. S., Goding, J. C., Caucci, L., ... King, M. A. (2018). Preliminary Investigation to Improve Point Spread Function Modeling for a Multi-Pinhole SPECT Camera. In 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings [8532750] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2017.8532750