Prenatal dexamethasone selectively decreases calretinin expression in the adult female lateral amygdala

Damian G. Zuloaga, David L. Carbone, Robert J Handa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Exposure to high levels of glucocorticoids (GCs) during early development results in lasting disturbances in emotional behavior in rodents. Inhibitory GABAergic neurons, classified by their expression of calcium binding proteins (CBPs), also contribute to stress-related behaviors and may be GC sensitive during development. Therefore, in the present study we investigated the effects of prenatal treatment with the glucocorticoid receptor agonist dexamethasone (DEX) on expression of calbindin and calretinin in brain areas critical to emotional regulation (basolateral/lateral amygdala and hippocampal CA1 and CA3 regions). Late gestational treatment with DEX (gestational days 18-22) significantly decreased the density of calretinin immunoreactive cells in the lateral amygdala of adult female offspring with no differences in the basolateral amygdala, hippocampal CA1, or CA3 regions. Moreover, there were no effects of gestational DEX treatment on calretinin expression in males. Calbindin expression in adulthood was unaltered within either amygdala or hippocampal subregion of either sex following prenatal DEX treatment. Together these findings indicate that late gestational DEX treatment causes a targeted reduction of calretinin within the lateral amygdala of females and this may be one mechanism through which developmental glucocorticoid exposure contributes to lasting alterations in emotional behavior.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalNeuroscience Letters
Volume521
Issue number2
DOIs
StatePublished - Jul 19 2012

Fingerprint

Calbindin 2
Amygdala
Dexamethasone
Hippocampal CA3 Region
Glucocorticoids
Hippocampal CA1 Region
Calbindins
GABAergic Neurons
Calcium-Binding Proteins
Glucocorticoid Receptors
Rodentia
Brain

Keywords

  • Calbindin
  • Calretinin
  • Dexamethasone
  • Glucocorticoid
  • Prenatal
  • Sex difference

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Prenatal dexamethasone selectively decreases calretinin expression in the adult female lateral amygdala. / Zuloaga, Damian G.; Carbone, David L.; Handa, Robert J.

In: Neuroscience Letters, Vol. 521, No. 2, 19.07.2012, p. 109-114.

Research output: Contribution to journalArticle

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