Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects

Alison G. Lee, Blake Le Grand, Hsiao Hsien Leon Hsu, Yueh Hsiu Mathilda Chiu, Kasey J. Brennan, Sonali Bose, Maria José Rosa, Kelly J. Brunst, Itai Kloog, Ander Wilson, Joel Schwartz, Wayne J Morgan, Brent A. Coull, Robert O. Wright, Andrea A. Baccarelli, Rosalind J. Wright

Research output: Contribution to journalArticle

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Abstract

Background: In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylation. Methods: We prospectively examined associations among prenatal PM2.5 exposure and child lung function and GSTP1 methylation in an urban pregnancy cohort study. We employed a validated satellite-based spatiotemporally resolved prediction model to estimate daily prenatal PM2.5 exposure over gestation. We used Baysian distributed lag interaction models (BDLIMs) to identify sensitive windows for prenatal PM2.5 exposure on child lung function and nasal epithelia GSTP1 methylation at age 7 years, and to examine effect modification by child sex. Results: BDLIMs identified a sensitive window for prenatal PM2.5 exposure at 35-40 weeks gestation [cumulative effect estimate (CEE) = - 0.10, 95%CI = - 0.19 to - 0.01, per μg/m3 increase in PM2.5] and at 36-40 weeks (CEE = - 0.12, 95%CI = - 0.20 to - 0.01) on FEV1 and FVC, respectively, in boys. BDLIMs also identified a sensitive window of exposure at 37-40 weeks gestation between higher prenatal PM2.5 exposure and increased GSTP1 percent methylation. The association between higher GSTP1 percent methylation and decreased FEV1 was borderline significant in the sample as a whole (β = - 0.37, SE = 0.20, p = 0.06) and in boys in stratified analyses (β = - 0.56, SE = 0.29, p = 0.05). Conclusions: Prenatal PM2.5 exposure in late pregnancy was associated with impaired early childhood lung function and hypermethylation of GSTPI in DNA isolated from nasal epithelial cells. There was a trend towards higher GSTP1 percent methylation being associated with reduced FEV1. All findings were most evident among boys.

Original languageEnglish (US)
Article number76
JournalRespiratory Research
Volume19
Issue number1
DOIs
StatePublished - Apr 27 2018

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Nasal Mucosa
Glutathione Transferase
Methylation
Lung
Pregnancy
Particulate Matter
Nose
Cohort Studies
Epithelial Cells
DNA

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation : Sex-specific effects. / Lee, Alison G.; Le Grand, Blake; Hsu, Hsiao Hsien Leon; Chiu, Yueh Hsiu Mathilda; Brennan, Kasey J.; Bose, Sonali; Rosa, Maria José; Brunst, Kelly J.; Kloog, Itai; Wilson, Ander; Schwartz, Joel; Morgan, Wayne J; Coull, Brent A.; Wright, Robert O.; Baccarelli, Andrea A.; Wright, Rosalind J.

In: Respiratory Research, Vol. 19, No. 1, 76, 27.04.2018.

Research output: Contribution to journalArticle

Lee, AG, Le Grand, B, Hsu, HHL, Chiu, YHM, Brennan, KJ, Bose, S, Rosa, MJ, Brunst, KJ, Kloog, I, Wilson, A, Schwartz, J, Morgan, WJ, Coull, BA, Wright, RO, Baccarelli, AA & Wright, RJ 2018, 'Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects', Respiratory Research, vol. 19, no. 1, 76. https://doi.org/10.1186/s12931-018-0774-3
Lee, Alison G. ; Le Grand, Blake ; Hsu, Hsiao Hsien Leon ; Chiu, Yueh Hsiu Mathilda ; Brennan, Kasey J. ; Bose, Sonali ; Rosa, Maria José ; Brunst, Kelly J. ; Kloog, Itai ; Wilson, Ander ; Schwartz, Joel ; Morgan, Wayne J ; Coull, Brent A. ; Wright, Robert O. ; Baccarelli, Andrea A. ; Wright, Rosalind J. / Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation : Sex-specific effects. In: Respiratory Research. 2018 ; Vol. 19, No. 1.
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abstract = "Background: In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylation. Methods: We prospectively examined associations among prenatal PM2.5 exposure and child lung function and GSTP1 methylation in an urban pregnancy cohort study. We employed a validated satellite-based spatiotemporally resolved prediction model to estimate daily prenatal PM2.5 exposure over gestation. We used Baysian distributed lag interaction models (BDLIMs) to identify sensitive windows for prenatal PM2.5 exposure on child lung function and nasal epithelia GSTP1 methylation at age 7 years, and to examine effect modification by child sex. Results: BDLIMs identified a sensitive window for prenatal PM2.5 exposure at 35-40 weeks gestation [cumulative effect estimate (CEE) = - 0.10, 95{\%}CI = - 0.19 to - 0.01, per μg/m3 increase in PM2.5] and at 36-40 weeks (CEE = - 0.12, 95{\%}CI = - 0.20 to - 0.01) on FEV1 and FVC, respectively, in boys. BDLIMs also identified a sensitive window of exposure at 37-40 weeks gestation between higher prenatal PM2.5 exposure and increased GSTP1 percent methylation. The association between higher GSTP1 percent methylation and decreased FEV1 was borderline significant in the sample as a whole (β = - 0.37, SE = 0.20, p = 0.06) and in boys in stratified analyses (β = - 0.56, SE = 0.29, p = 0.05). Conclusions: Prenatal PM2.5 exposure in late pregnancy was associated with impaired early childhood lung function and hypermethylation of GSTPI in DNA isolated from nasal epithelial cells. There was a trend towards higher GSTP1 percent methylation being associated with reduced FEV1. All findings were most evident among boys.",
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T2 - Sex-specific effects

AU - Lee, Alison G.

AU - Le Grand, Blake

AU - Hsu, Hsiao Hsien Leon

AU - Chiu, Yueh Hsiu Mathilda

AU - Brennan, Kasey J.

AU - Bose, Sonali

AU - Rosa, Maria José

AU - Brunst, Kelly J.

AU - Kloog, Itai

AU - Wilson, Ander

AU - Schwartz, Joel

AU - Morgan, Wayne J

AU - Coull, Brent A.

AU - Wright, Robert O.

AU - Baccarelli, Andrea A.

AU - Wright, Rosalind J.

PY - 2018/4/27

Y1 - 2018/4/27

N2 - Background: In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylation. Methods: We prospectively examined associations among prenatal PM2.5 exposure and child lung function and GSTP1 methylation in an urban pregnancy cohort study. We employed a validated satellite-based spatiotemporally resolved prediction model to estimate daily prenatal PM2.5 exposure over gestation. We used Baysian distributed lag interaction models (BDLIMs) to identify sensitive windows for prenatal PM2.5 exposure on child lung function and nasal epithelia GSTP1 methylation at age 7 years, and to examine effect modification by child sex. Results: BDLIMs identified a sensitive window for prenatal PM2.5 exposure at 35-40 weeks gestation [cumulative effect estimate (CEE) = - 0.10, 95%CI = - 0.19 to - 0.01, per μg/m3 increase in PM2.5] and at 36-40 weeks (CEE = - 0.12, 95%CI = - 0.20 to - 0.01) on FEV1 and FVC, respectively, in boys. BDLIMs also identified a sensitive window of exposure at 37-40 weeks gestation between higher prenatal PM2.5 exposure and increased GSTP1 percent methylation. The association between higher GSTP1 percent methylation and decreased FEV1 was borderline significant in the sample as a whole (β = - 0.37, SE = 0.20, p = 0.06) and in boys in stratified analyses (β = - 0.56, SE = 0.29, p = 0.05). Conclusions: Prenatal PM2.5 exposure in late pregnancy was associated with impaired early childhood lung function and hypermethylation of GSTPI in DNA isolated from nasal epithelial cells. There was a trend towards higher GSTP1 percent methylation being associated with reduced FEV1. All findings were most evident among boys.

AB - Background: In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylation. Methods: We prospectively examined associations among prenatal PM2.5 exposure and child lung function and GSTP1 methylation in an urban pregnancy cohort study. We employed a validated satellite-based spatiotemporally resolved prediction model to estimate daily prenatal PM2.5 exposure over gestation. We used Baysian distributed lag interaction models (BDLIMs) to identify sensitive windows for prenatal PM2.5 exposure on child lung function and nasal epithelia GSTP1 methylation at age 7 years, and to examine effect modification by child sex. Results: BDLIMs identified a sensitive window for prenatal PM2.5 exposure at 35-40 weeks gestation [cumulative effect estimate (CEE) = - 0.10, 95%CI = - 0.19 to - 0.01, per μg/m3 increase in PM2.5] and at 36-40 weeks (CEE = - 0.12, 95%CI = - 0.20 to - 0.01) on FEV1 and FVC, respectively, in boys. BDLIMs also identified a sensitive window of exposure at 37-40 weeks gestation between higher prenatal PM2.5 exposure and increased GSTP1 percent methylation. The association between higher GSTP1 percent methylation and decreased FEV1 was borderline significant in the sample as a whole (β = - 0.37, SE = 0.20, p = 0.06) and in boys in stratified analyses (β = - 0.56, SE = 0.29, p = 0.05). Conclusions: Prenatal PM2.5 exposure in late pregnancy was associated with impaired early childhood lung function and hypermethylation of GSTPI in DNA isolated from nasal epithelial cells. There was a trend towards higher GSTP1 percent methylation being associated with reduced FEV1. All findings were most evident among boys.

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