Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients

Ian K. Komenaka, Chiu-Hsieh Hsu, Maria Elena Martinez, Marcia E. Bouton, Boo Ghee Low, Jason A. Salganick, Jesse Nodora, Michael L. Hibbard, Chandra Jha

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction. Preoperative chemotherapy (PC) for operable breast cancer has shown significant benefits in prospective trials. Many patients are treated in the community setting and some may question the applicability of PC outside the university setting. Methods. Retrospective review was performed of stage II and IIIA breast cancer patients treated from January 2002 to July 2009. Fifty-three of 57 patients who underwent PC were matched based on age, tumor size, and hormone receptor status with 53 patients who did not undergo PC. Differences in patient compliance with physician recommendations for all types of adjuvant therapy were evaluated. Crude odds ratios and adjusted odds ratios derived from conditional logistic regression models were calculated. Results. There were 106 patients included. Patient compliance with chemotherapy was better in the PC group than in the adjuvant chemotherapy (AC) group (100% versus 70%;p =.0001). Similarly, more patients in the PC group completed radiation therapy (96% versus 65%; p =.0003) and initiated hormonal therapy (100% versus 62%; p =.0001). Conditional logistic regression revealed that higher pathologic stage and current cigarette smoking were associated with poorer compliance with chemotherapy. For radiation therapy, the univariate model revealed that compliance with chemotherapy and being employed were associated with completion of radiation, whereas current cigarette smoking and larger pathologic size were associated with poorer compliance with radiation. For hormonal therapy, current cigarette smokers were more likely to be noncompliant with initiation of hormonal therapy. Conclusions. PC for operable breast cancer can improve patient compliance with chemotherapy. Current cigarette smokers were more likely to be noncompliant with all types of adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)742-751
Number of pages10
JournalOncologist
Volume16
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Breast Neoplasms
Drug Therapy
Patient Compliance
Therapeutics
Logistic Models
Tobacco Products
Radiotherapy
Smoking
Odds Ratio
Radiation
Adjuvant Chemotherapy
Hormones
Physicians
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients. / Komenaka, Ian K.; Hsu, Chiu-Hsieh; Martinez, Maria Elena; Bouton, Marcia E.; Low, Boo Ghee; Salganick, Jason A.; Nodora, Jesse; Hibbard, Michael L.; Jha, Chandra.

In: Oncologist, Vol. 16, No. 6, 06.2011, p. 742-751.

Research output: Contribution to journalArticle

Komenaka, Ian K. ; Hsu, Chiu-Hsieh ; Martinez, Maria Elena ; Bouton, Marcia E. ; Low, Boo Ghee ; Salganick, Jason A. ; Nodora, Jesse ; Hibbard, Michael L. ; Jha, Chandra. / Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients. In: Oncologist. 2011 ; Vol. 16, No. 6. pp. 742-751.
@article{24af579039224ae3bc4da7310c5617da,
title = "Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients",
abstract = "Introduction. Preoperative chemotherapy (PC) for operable breast cancer has shown significant benefits in prospective trials. Many patients are treated in the community setting and some may question the applicability of PC outside the university setting. Methods. Retrospective review was performed of stage II and IIIA breast cancer patients treated from January 2002 to July 2009. Fifty-three of 57 patients who underwent PC were matched based on age, tumor size, and hormone receptor status with 53 patients who did not undergo PC. Differences in patient compliance with physician recommendations for all types of adjuvant therapy were evaluated. Crude odds ratios and adjusted odds ratios derived from conditional logistic regression models were calculated. Results. There were 106 patients included. Patient compliance with chemotherapy was better in the PC group than in the adjuvant chemotherapy (AC) group (100{\%} versus 70{\%};p =.0001). Similarly, more patients in the PC group completed radiation therapy (96{\%} versus 65{\%}; p =.0003) and initiated hormonal therapy (100{\%} versus 62{\%}; p =.0001). Conditional logistic regression revealed that higher pathologic stage and current cigarette smoking were associated with poorer compliance with chemotherapy. For radiation therapy, the univariate model revealed that compliance with chemotherapy and being employed were associated with completion of radiation, whereas current cigarette smoking and larger pathologic size were associated with poorer compliance with radiation. For hormonal therapy, current cigarette smokers were more likely to be noncompliant with initiation of hormonal therapy. Conclusions. PC for operable breast cancer can improve patient compliance with chemotherapy. Current cigarette smokers were more likely to be noncompliant with all types of adjuvant therapy.",
author = "Komenaka, {Ian K.} and Chiu-Hsieh Hsu and Martinez, {Maria Elena} and Bouton, {Marcia E.} and Low, {Boo Ghee} and Salganick, {Jason A.} and Jesse Nodora and Hibbard, {Michael L.} and Chandra Jha",
year = "2011",
month = "6",
doi = "10.1634/theoncologist.2010-0266",
language = "English (US)",
volume = "16",
pages = "742--751",
journal = "Oncologist",
issn = "1083-7159",
publisher = "AlphaMed Press",
number = "6",

}

TY - JOUR

T1 - Preoperative chemotherapy for operable breast cancer is associated with better compliance with adjuvant therapy in matched stage II and IIIA patients

AU - Komenaka, Ian K.

AU - Hsu, Chiu-Hsieh

AU - Martinez, Maria Elena

AU - Bouton, Marcia E.

AU - Low, Boo Ghee

AU - Salganick, Jason A.

AU - Nodora, Jesse

AU - Hibbard, Michael L.

AU - Jha, Chandra

PY - 2011/6

Y1 - 2011/6

N2 - Introduction. Preoperative chemotherapy (PC) for operable breast cancer has shown significant benefits in prospective trials. Many patients are treated in the community setting and some may question the applicability of PC outside the university setting. Methods. Retrospective review was performed of stage II and IIIA breast cancer patients treated from January 2002 to July 2009. Fifty-three of 57 patients who underwent PC were matched based on age, tumor size, and hormone receptor status with 53 patients who did not undergo PC. Differences in patient compliance with physician recommendations for all types of adjuvant therapy were evaluated. Crude odds ratios and adjusted odds ratios derived from conditional logistic regression models were calculated. Results. There were 106 patients included. Patient compliance with chemotherapy was better in the PC group than in the adjuvant chemotherapy (AC) group (100% versus 70%;p =.0001). Similarly, more patients in the PC group completed radiation therapy (96% versus 65%; p =.0003) and initiated hormonal therapy (100% versus 62%; p =.0001). Conditional logistic regression revealed that higher pathologic stage and current cigarette smoking were associated with poorer compliance with chemotherapy. For radiation therapy, the univariate model revealed that compliance with chemotherapy and being employed were associated with completion of radiation, whereas current cigarette smoking and larger pathologic size were associated with poorer compliance with radiation. For hormonal therapy, current cigarette smokers were more likely to be noncompliant with initiation of hormonal therapy. Conclusions. PC for operable breast cancer can improve patient compliance with chemotherapy. Current cigarette smokers were more likely to be noncompliant with all types of adjuvant therapy.

AB - Introduction. Preoperative chemotherapy (PC) for operable breast cancer has shown significant benefits in prospective trials. Many patients are treated in the community setting and some may question the applicability of PC outside the university setting. Methods. Retrospective review was performed of stage II and IIIA breast cancer patients treated from January 2002 to July 2009. Fifty-three of 57 patients who underwent PC were matched based on age, tumor size, and hormone receptor status with 53 patients who did not undergo PC. Differences in patient compliance with physician recommendations for all types of adjuvant therapy were evaluated. Crude odds ratios and adjusted odds ratios derived from conditional logistic regression models were calculated. Results. There were 106 patients included. Patient compliance with chemotherapy was better in the PC group than in the adjuvant chemotherapy (AC) group (100% versus 70%;p =.0001). Similarly, more patients in the PC group completed radiation therapy (96% versus 65%; p =.0003) and initiated hormonal therapy (100% versus 62%; p =.0001). Conditional logistic regression revealed that higher pathologic stage and current cigarette smoking were associated with poorer compliance with chemotherapy. For radiation therapy, the univariate model revealed that compliance with chemotherapy and being employed were associated with completion of radiation, whereas current cigarette smoking and larger pathologic size were associated with poorer compliance with radiation. For hormonal therapy, current cigarette smokers were more likely to be noncompliant with initiation of hormonal therapy. Conclusions. PC for operable breast cancer can improve patient compliance with chemotherapy. Current cigarette smokers were more likely to be noncompliant with all types of adjuvant therapy.

UR - http://www.scopus.com/inward/record.url?scp=79959581565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959581565&partnerID=8YFLogxK

U2 - 10.1634/theoncologist.2010-0266

DO - 10.1634/theoncologist.2010-0266

M3 - Article

C2 - 21558134

AN - SCOPUS:79959581565

VL - 16

SP - 742

EP - 751

JO - Oncologist

JF - Oncologist

SN - 1083-7159

IS - 6

ER -