We report on experiments which show that liquid microdroplets are very efficient in hard x-ray generation. We make a comparative study of hard x-ray emission from 15 μm methanol microdroplets and a plain slab target of similar atomic composition at similar laser intensities. The hard X-ray yield from droplet plasmas is about 35 times more than that obtained from solid plasmas. A prepulse that is about 10ns and at least 2% in intensity of the main pulse is essential for hard x-ray generation from the droplets at about 10 15 W cm -2. A hot electron temperature of 36 keV is measured from the droplets at 8 × 10 14 W cm -2; three times higher intensity is needed to obtain similar hot electron temperature from solid plasmas that have similar atomic composition. We use 1D-PIC simulation to obtain qualitative correlation to the experimental observations.