Presence and development with age of aminopeptidase(S) in tears of children and other mammals

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Proteolytic enzymes are known to appear in tears only following trauma to the cornea. Aminopeptidases, enzymes involved in the final degradation of proteins to free amino acids, were measured and partially characterized for substrate specificity in normal human and animal tears. In all species tested, aminopeptidase activity was greatest for methionine 03b2-naphthylamide of the various synthetic analogs of N-terminal L-amino acids. The substrate specificities for aminopeptidase(s) in tears for 11 different mammals were very similar. In children aminopeptidase activity decreased with increasing age and was unaffected by nutritional status.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalOphthalmic Research
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

Keywords

  • Age dependence
  • Aminopeptidases
  • Dog
  • Human
  • L-Amino acids
  • N-terminal enzyme
  • Rabbit
  • Rhesus monkey
  • Species dif-ferences
  • Specific activity
  • Tears
  • Tears
  • Tears
  • Tears

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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