Pretreatment with a dopamine D1-receptor antagonist prevents metabolic activation by cocaine

William L. Thomas, Erick S. Cooke, Ronald P. Hammer

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The pharmacological mechanism underlying metabolic activation of the rat extrapyramidal system by acute cocaine was examined using the quantitative 2-deoxyglucose autoradiographic method. Pretreatment with a selective dopamine D1-like receptor antagonist, SCH 23390, prevented cocaine-induced metabolic activation in the entopeduncular nucleus and substantia nigra pars reticulata in a dose-dependent manner. These results suggest that activity in striatonigral circuits is induced by stimulation of D1-like receptors by dopamine in the presence of acute cocaine.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Issue number2
StatePublished - Aug 25 1995
Externally publishedYes


  • 2-deoxyglucose
  • Cocaine
  • D-receptor
  • Striatum
  • Substantia nigra pars reticulata

ASJC Scopus subject areas

  • Neuroscience(all)


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