We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.
|Original language||English (US)|
|Number of pages||6|
|Journal||Cellular and molecular biology (Noisy-le-Grand, France)|
|State||Published - Nov 1994|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology