Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

I. V. Smirnov, B. G. Feuerstein, M. Pellarin, L. J. Marton, D. F. Deen, H. S. Basu

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.

Original languageEnglish (US)
Pages (from-to)975-980
Number of pages6
JournalCellular and molecular biology (Noisy-le-Grand, France)
Volume40
Issue number7
StatePublished - Nov 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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