Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

I. V. Smirnov, Burt G.F. Feuerstein, M. Pellarin, L. J. Marton, D. F. Deen, H. S. Basu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.

Original languageEnglish (US)
Pages (from-to)975-980
Number of pages6
JournalCellular and molecular biology (Noisy-le-Grand, France)
Volume40
Issue number7
StatePublished - Nov 1994
Externally publishedYes

Fingerprint

Polyamines
Etoposide
Cytotoxicity
Brain Neoplasms
Tumors
Brain
Cells
Topoisomerase II Inhibitors
Nuclear Matrix
DNA
BE 4-4-4-4

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology

Cite this

@article{cc3d044f8ea44e9dbe42c62679137767,
title = "Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.",
abstract = "We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.",
author = "Smirnov, {I. V.} and Feuerstein, {Burt G.F.} and M. Pellarin and Marton, {L. J.} and Deen, {D. F.} and Basu, {H. S.}",
year = "1994",
month = "11",
language = "English (US)",
volume = "40",
pages = "975--980",
journal = "Cellular and Molecular Biology",
issn = "0145-5680",
publisher = "Cellular and Molecular Biology Association",
number = "7",

}

TY - JOUR

T1 - Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.

AU - Smirnov, I. V.

AU - Feuerstein, Burt G.F.

AU - Pellarin, M.

AU - Marton, L. J.

AU - Deen, D. F.

AU - Basu, H. S.

PY - 1994/11

Y1 - 1994/11

N2 - We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.

AB - We studied whether pretreatment of U-251 MG human brain tumor cells with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the topoisomerase II inhibitor etoposide. We found that BE-4-4-4-4 protected cells from the cytotoxic effects of etoposide. Possible mechanisms for this protection may be related to enhanced DNA-nuclear matrix association in analog-treated cells.

UR - http://www.scopus.com/inward/record.url?scp=0028540630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028540630&partnerID=8YFLogxK

M3 - Article

C2 - 7849564

AN - SCOPUS:0028540630

VL - 40

SP - 975

EP - 980

JO - Cellular and Molecular Biology

JF - Cellular and Molecular Biology

SN - 0145-5680

IS - 7

ER -