Prevalence of asthma and atopy in two areas of West and East Germany

Erika Von Mutius, Fernando Martinez, Christian Fritzsch, Thomas Nicolai, Gabriele Roell, Hans Heinrich Thiemann

Research output: Contribution to journalArticle

797 Citations (Scopus)

Abstract

The German reunification offers a unique opportunity to study the impact of environmental factors on the development of childhood respiratory and allergic disorders in ethnically similar populations. We investigated the prevalence of asthma, hay fever, atopy, and bronchial hyperresponsiveness (BHR) in 9- to 11-year old children in West Germany (n = 5,030) and East Germany (n = 2,623). A self-administered questionnaire was distributed to the parents. Children underwent cold air challenge and allergy skin prick tests. Atopic sensitization was considerably more frequent in West German children than in their peers in East Germany (36.7% versus 18.2%; odds ratio [OR] = 2.6, p < 0.0001). The prevalence of current asthma and hay fever was significantly higher in West Germany when compared with that in East Germany (5.9% versus 3.9%; OR = 1.5, p < 0.0001 and 8.6% versus 2.7%; OR = 3.4, p < 0.0001, respectively). Bronchitis, however, was more prevalent in East Germany than in the western part of the country. The prevalence of BHR as assessed by cold air challenge was higher in West Germany compared with that in East Germany (8.3% versus 5.5%, OR = 1.6, p < 0.001). Logistic regression showed that the West German study area was no longer a significant independent determinant of asthma once sensitization to mites, cats, and pollen was taken into account. We conclude that sensitization to aeroallergens is strikingly more frequent in West Germany than in East Germany and this may explain the differences in the prevalence of asthma and hay fever between the two parts of the country. We speculate that Western lifestyle is a risk factor for the development of atopy.

Original languageEnglish (US)
Pages (from-to)358-364
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume149
Issue number2 I
StatePublished - Feb 1994
Externally publishedYes

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East Germany
West Germany
Asthma
Seasonal Allergic Rhinitis
Odds Ratio
Air
Bronchitis
Mites
Pollen
Skin Tests
Life Style
Hypersensitivity
Cats
Parents
Logistic Models
Population

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Von Mutius, E., Martinez, F., Fritzsch, C., Nicolai, T., Roell, G., & Thiemann, H. H. (1994). Prevalence of asthma and atopy in two areas of West and East Germany. American Journal of Respiratory and Critical Care Medicine, 149(2 I), 358-364.

Prevalence of asthma and atopy in two areas of West and East Germany. / Von Mutius, Erika; Martinez, Fernando; Fritzsch, Christian; Nicolai, Thomas; Roell, Gabriele; Thiemann, Hans Heinrich.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 149, No. 2 I, 02.1994, p. 358-364.

Research output: Contribution to journalArticle

Von Mutius, E, Martinez, F, Fritzsch, C, Nicolai, T, Roell, G & Thiemann, HH 1994, 'Prevalence of asthma and atopy in two areas of West and East Germany', American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 2 I, pp. 358-364.
Von Mutius, Erika ; Martinez, Fernando ; Fritzsch, Christian ; Nicolai, Thomas ; Roell, Gabriele ; Thiemann, Hans Heinrich. / Prevalence of asthma and atopy in two areas of West and East Germany. In: American Journal of Respiratory and Critical Care Medicine. 1994 ; Vol. 149, No. 2 I. pp. 358-364.
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