Prevalence of Pulmonary Hypertension and its Influence on Survival in Patients with Advanced Chronic Obstructive Pulmonary Disease Prior to Lung Transplantation

Don Hayes, Sylvester M. Black, Joseph D. Tobias, Heidi - Mansour, Bryan A. Whitson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Prevalence of pulmonary hypertension (PH) and its influence on survival in chronic obstructive pulmonary disease (COPD) are not well studied in the lung allocation score (LAS) era.Methods: The UNOS database was queried from 2005 to 2013 to identify first-time adult lung transplant candidates with COPD who were tracked from wait list entry date until death or censoring to determine both prevalence and influence of PH. Using right heart catheterization measurements, mild PH was defined as mean pulmonary artery pressure (mPAP) ≥ 25 mmHg and severe ≥ 35 mmHg.Results: Of 1315 COPD candidates not transplanted, 1243 were used for survival analysis using Cox proportional hazards models, and 1010 (mild PH) and 244 (severe PH) were used for propensity score matching, respectively. A total of 52% (652) of subjects had PH mPAP ≥ 25 mmHg. Univariate analysis revealed significant differences in survival for mild PH (HR = 1.769; 95% CI: 1.331, 2.351; p <0.001) and severe PH (HR = 3.271; 95% CI: 2.311, 4.630; p <0.001). Kaplan-Meier survival function demonstrated significant disparities for mild PH (Log-rank test: Chi-square1: 15.87, p <0.0001) and severe PH (Log-rank test: Chi-square1: 50.13, p <0.0001). Multivariate Cox models identified significant risk for death for mild PH (HR = 1.987; 95% CI: 1.484, 2.662; p <0.001) and severe PH (HR = 3.432; 95% CI: 2.410, 4.888; p <0.001). Propensity score matching confirmed increased mortality hazard associated with mild PH (HR = 2.280; 95% CI: 1.425, 3.649; p = 0.001) and severe PH (HR = 7.000; 95% CI: 2.455, 19.957; p <0.001).Conclusions: PH is highly prevalent in advanced COPD and associated with a significantly higher risk for mortality.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalCOPD: Journal of Chronic Obstructive Pulmonary Disease
Volume13
Issue number1
DOIs
StatePublished - Jan 2 2016

Fingerprint

Lung Transplantation
Pulmonary Hypertension
Chronic Obstructive Pulmonary Disease
Survival
Propensity Score
Proportional Hazards Models
Pulmonary Artery
Pressure
Lung
Mortality
Cardiac Catheterization
Survival Analysis

Keywords

  • chronic obstructive pulmonary disease
  • lung transplantation
  • pulmonary hypertension
  • survival

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Prevalence of Pulmonary Hypertension and its Influence on Survival in Patients with Advanced Chronic Obstructive Pulmonary Disease Prior to Lung Transplantation. / Hayes, Don; Black, Sylvester M.; Tobias, Joseph D.; Mansour, Heidi -; Whitson, Bryan A.

In: COPD: Journal of Chronic Obstructive Pulmonary Disease, Vol. 13, No. 1, 02.01.2016, p. 50-56.

Research output: Contribution to journalArticle

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abstract = "Introduction: Prevalence of pulmonary hypertension (PH) and its influence on survival in chronic obstructive pulmonary disease (COPD) are not well studied in the lung allocation score (LAS) era.Methods: The UNOS database was queried from 2005 to 2013 to identify first-time adult lung transplant candidates with COPD who were tracked from wait list entry date until death or censoring to determine both prevalence and influence of PH. Using right heart catheterization measurements, mild PH was defined as mean pulmonary artery pressure (mPAP) ≥ 25 mmHg and severe ≥ 35 mmHg.Results: Of 1315 COPD candidates not transplanted, 1243 were used for survival analysis using Cox proportional hazards models, and 1010 (mild PH) and 244 (severe PH) were used for propensity score matching, respectively. A total of 52{\%} (652) of subjects had PH mPAP ≥ 25 mmHg. Univariate analysis revealed significant differences in survival for mild PH (HR = 1.769; 95{\%} CI: 1.331, 2.351; p <0.001) and severe PH (HR = 3.271; 95{\%} CI: 2.311, 4.630; p <0.001). Kaplan-Meier survival function demonstrated significant disparities for mild PH (Log-rank test: Chi-square1: 15.87, p <0.0001) and severe PH (Log-rank test: Chi-square1: 50.13, p <0.0001). Multivariate Cox models identified significant risk for death for mild PH (HR = 1.987; 95{\%} CI: 1.484, 2.662; p <0.001) and severe PH (HR = 3.432; 95{\%} CI: 2.410, 4.888; p <0.001). Propensity score matching confirmed increased mortality hazard associated with mild PH (HR = 2.280; 95{\%} CI: 1.425, 3.649; p = 0.001) and severe PH (HR = 7.000; 95{\%} CI: 2.455, 19.957; p <0.001).Conclusions: PH is highly prevalent in advanced COPD and associated with a significantly higher risk for mortality.",
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AU - Hayes, Don

AU - Black, Sylvester M.

AU - Tobias, Joseph D.

AU - Mansour, Heidi -

AU - Whitson, Bryan A.

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N2 - Introduction: Prevalence of pulmonary hypertension (PH) and its influence on survival in chronic obstructive pulmonary disease (COPD) are not well studied in the lung allocation score (LAS) era.Methods: The UNOS database was queried from 2005 to 2013 to identify first-time adult lung transplant candidates with COPD who were tracked from wait list entry date until death or censoring to determine both prevalence and influence of PH. Using right heart catheterization measurements, mild PH was defined as mean pulmonary artery pressure (mPAP) ≥ 25 mmHg and severe ≥ 35 mmHg.Results: Of 1315 COPD candidates not transplanted, 1243 were used for survival analysis using Cox proportional hazards models, and 1010 (mild PH) and 244 (severe PH) were used for propensity score matching, respectively. A total of 52% (652) of subjects had PH mPAP ≥ 25 mmHg. Univariate analysis revealed significant differences in survival for mild PH (HR = 1.769; 95% CI: 1.331, 2.351; p <0.001) and severe PH (HR = 3.271; 95% CI: 2.311, 4.630; p <0.001). Kaplan-Meier survival function demonstrated significant disparities for mild PH (Log-rank test: Chi-square1: 15.87, p <0.0001) and severe PH (Log-rank test: Chi-square1: 50.13, p <0.0001). Multivariate Cox models identified significant risk for death for mild PH (HR = 1.987; 95% CI: 1.484, 2.662; p <0.001) and severe PH (HR = 3.432; 95% CI: 2.410, 4.888; p <0.001). Propensity score matching confirmed increased mortality hazard associated with mild PH (HR = 2.280; 95% CI: 1.425, 3.649; p = 0.001) and severe PH (HR = 7.000; 95% CI: 2.455, 19.957; p <0.001).Conclusions: PH is highly prevalent in advanced COPD and associated with a significantly higher risk for mortality.

AB - Introduction: Prevalence of pulmonary hypertension (PH) and its influence on survival in chronic obstructive pulmonary disease (COPD) are not well studied in the lung allocation score (LAS) era.Methods: The UNOS database was queried from 2005 to 2013 to identify first-time adult lung transplant candidates with COPD who were tracked from wait list entry date until death or censoring to determine both prevalence and influence of PH. Using right heart catheterization measurements, mild PH was defined as mean pulmonary artery pressure (mPAP) ≥ 25 mmHg and severe ≥ 35 mmHg.Results: Of 1315 COPD candidates not transplanted, 1243 were used for survival analysis using Cox proportional hazards models, and 1010 (mild PH) and 244 (severe PH) were used for propensity score matching, respectively. A total of 52% (652) of subjects had PH mPAP ≥ 25 mmHg. Univariate analysis revealed significant differences in survival for mild PH (HR = 1.769; 95% CI: 1.331, 2.351; p <0.001) and severe PH (HR = 3.271; 95% CI: 2.311, 4.630; p <0.001). Kaplan-Meier survival function demonstrated significant disparities for mild PH (Log-rank test: Chi-square1: 15.87, p <0.0001) and severe PH (Log-rank test: Chi-square1: 50.13, p <0.0001). Multivariate Cox models identified significant risk for death for mild PH (HR = 1.987; 95% CI: 1.484, 2.662; p <0.001) and severe PH (HR = 3.432; 95% CI: 2.410, 4.888; p <0.001). Propensity score matching confirmed increased mortality hazard associated with mild PH (HR = 2.280; 95% CI: 1.425, 3.649; p = 0.001) and severe PH (HR = 7.000; 95% CI: 2.455, 19.957; p <0.001).Conclusions: PH is highly prevalent in advanced COPD and associated with a significantly higher risk for mortality.

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