Prevention of colorectal cancer

Michael P Lance, Patricia Thompson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Colorectal cancer (CRC) is a malignant epithelial neoplasm (adenocarcinoma) developing in the glandular tissue of the colon or rectum. The great majority of CRCs develop from adenomatous colorectal polyps in a process called the adenoma-carcinoma sequence (Muto et al., Cancer 36(6):2251–2270, 1975). Colorectal polyps are a histopathologic group of benign lesions that include hyperplastic and adenomatous polyps that project above the surrounding mucosa as well as the less common, non-polypoid polyps. The adenomatous polyps (adenomas) are benign, neoplastic precursors that arise in the colorectal glandular epithelium. In the United States (USA), colorectal adenoma (CRA) prevalence is approximately 25 % by age 50 and rises to around 50 % by age 70. The histological hallmarks of a CRA are altered glandular architecture and dysplasia of the epithelium. A benign CRA progresses to invasive CRC when the dysplastic cells gain the capacity to invade through the muscularis mucosa. The development of invasive cancer from the earliest CRA may take from years to decades. While most CRCs develop from CRAs, the slow rate of progress results in less than 10 % ever progressing to CRC. In this chapter, we review the molecular characteristics of the disease and provide an update on the epidemiology including reviewing evidence for established and suspected risk factors for CRC. Given the dramatic impact that screening and early detection have had on reducing the incidence and mortality suspected of CRC and death from CRC, we have included a detailed review of the different screening recommendations and their efficacy.

Original languageEnglish (US)
Title of host publicationFundamentals of Cancer Prevention, Third Edition
PublisherSpringer Berlin Heidelberg
Pages377-408
Number of pages32
ISBN (Print)9783642389832, 9783642389825
DOIs
StatePublished - Jan 1 2014

Fingerprint

Colorectal Neoplasms
Adenoma
Adenomatous Polyps
Polyps
Mucous Membrane
Epithelium
Carcinoma
Rectum
Colon
Epidemiology
Adenocarcinoma
Mortality
Incidence
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lance, M. P., & Thompson, P. (2014). Prevention of colorectal cancer. In Fundamentals of Cancer Prevention, Third Edition (pp. 377-408). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-38983-2_13

Prevention of colorectal cancer. / Lance, Michael P; Thompson, Patricia.

Fundamentals of Cancer Prevention, Third Edition. Springer Berlin Heidelberg, 2014. p. 377-408.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lance, MP & Thompson, P 2014, Prevention of colorectal cancer. in Fundamentals of Cancer Prevention, Third Edition. Springer Berlin Heidelberg, pp. 377-408. https://doi.org/10.1007/978-3-642-38983-2_13
Lance MP, Thompson P. Prevention of colorectal cancer. In Fundamentals of Cancer Prevention, Third Edition. Springer Berlin Heidelberg. 2014. p. 377-408 https://doi.org/10.1007/978-3-642-38983-2_13
Lance, Michael P ; Thompson, Patricia. / Prevention of colorectal cancer. Fundamentals of Cancer Prevention, Third Edition. Springer Berlin Heidelberg, 2014. pp. 377-408
@inbook{65f50165dc744a0898ca6ba7af83964f,
title = "Prevention of colorectal cancer",
abstract = "Colorectal cancer (CRC) is a malignant epithelial neoplasm (adenocarcinoma) developing in the glandular tissue of the colon or rectum. The great majority of CRCs develop from adenomatous colorectal polyps in a process called the adenoma-carcinoma sequence (Muto et al., Cancer 36(6):2251–2270, 1975). Colorectal polyps are a histopathologic group of benign lesions that include hyperplastic and adenomatous polyps that project above the surrounding mucosa as well as the less common, non-polypoid polyps. The adenomatous polyps (adenomas) are benign, neoplastic precursors that arise in the colorectal glandular epithelium. In the United States (USA), colorectal adenoma (CRA) prevalence is approximately 25 {\%} by age 50 and rises to around 50 {\%} by age 70. The histological hallmarks of a CRA are altered glandular architecture and dysplasia of the epithelium. A benign CRA progresses to invasive CRC when the dysplastic cells gain the capacity to invade through the muscularis mucosa. The development of invasive cancer from the earliest CRA may take from years to decades. While most CRCs develop from CRAs, the slow rate of progress results in less than 10 {\%} ever progressing to CRC. In this chapter, we review the molecular characteristics of the disease and provide an update on the epidemiology including reviewing evidence for established and suspected risk factors for CRC. Given the dramatic impact that screening and early detection have had on reducing the incidence and mortality suspected of CRC and death from CRC, we have included a detailed review of the different screening recommendations and their efficacy.",
author = "Lance, {Michael P} and Patricia Thompson",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-3-642-38983-2_13",
language = "English (US)",
isbn = "9783642389832",
pages = "377--408",
booktitle = "Fundamentals of Cancer Prevention, Third Edition",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Prevention of colorectal cancer

AU - Lance, Michael P

AU - Thompson, Patricia

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Colorectal cancer (CRC) is a malignant epithelial neoplasm (adenocarcinoma) developing in the glandular tissue of the colon or rectum. The great majority of CRCs develop from adenomatous colorectal polyps in a process called the adenoma-carcinoma sequence (Muto et al., Cancer 36(6):2251–2270, 1975). Colorectal polyps are a histopathologic group of benign lesions that include hyperplastic and adenomatous polyps that project above the surrounding mucosa as well as the less common, non-polypoid polyps. The adenomatous polyps (adenomas) are benign, neoplastic precursors that arise in the colorectal glandular epithelium. In the United States (USA), colorectal adenoma (CRA) prevalence is approximately 25 % by age 50 and rises to around 50 % by age 70. The histological hallmarks of a CRA are altered glandular architecture and dysplasia of the epithelium. A benign CRA progresses to invasive CRC when the dysplastic cells gain the capacity to invade through the muscularis mucosa. The development of invasive cancer from the earliest CRA may take from years to decades. While most CRCs develop from CRAs, the slow rate of progress results in less than 10 % ever progressing to CRC. In this chapter, we review the molecular characteristics of the disease and provide an update on the epidemiology including reviewing evidence for established and suspected risk factors for CRC. Given the dramatic impact that screening and early detection have had on reducing the incidence and mortality suspected of CRC and death from CRC, we have included a detailed review of the different screening recommendations and their efficacy.

AB - Colorectal cancer (CRC) is a malignant epithelial neoplasm (adenocarcinoma) developing in the glandular tissue of the colon or rectum. The great majority of CRCs develop from adenomatous colorectal polyps in a process called the adenoma-carcinoma sequence (Muto et al., Cancer 36(6):2251–2270, 1975). Colorectal polyps are a histopathologic group of benign lesions that include hyperplastic and adenomatous polyps that project above the surrounding mucosa as well as the less common, non-polypoid polyps. The adenomatous polyps (adenomas) are benign, neoplastic precursors that arise in the colorectal glandular epithelium. In the United States (USA), colorectal adenoma (CRA) prevalence is approximately 25 % by age 50 and rises to around 50 % by age 70. The histological hallmarks of a CRA are altered glandular architecture and dysplasia of the epithelium. A benign CRA progresses to invasive CRC when the dysplastic cells gain the capacity to invade through the muscularis mucosa. The development of invasive cancer from the earliest CRA may take from years to decades. While most CRCs develop from CRAs, the slow rate of progress results in less than 10 % ever progressing to CRC. In this chapter, we review the molecular characteristics of the disease and provide an update on the epidemiology including reviewing evidence for established and suspected risk factors for CRC. Given the dramatic impact that screening and early detection have had on reducing the incidence and mortality suspected of CRC and death from CRC, we have included a detailed review of the different screening recommendations and their efficacy.

UR - http://www.scopus.com/inward/record.url?scp=84955740982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955740982&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-38983-2_13

DO - 10.1007/978-3-642-38983-2_13

M3 - Chapter

SN - 9783642389832

SN - 9783642389825

SP - 377

EP - 408

BT - Fundamentals of Cancer Prevention, Third Edition

PB - Springer Berlin Heidelberg

ER -