Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection

Z. Zhang, M. Araghi-Niknam, B. Liang, P. Inserra, S. K. Ardestani, S. Jiang, Hsiao-Hui Chow, Ronald R Watson

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Female C57BL/6 mice infected with the LP-BM5 leukaemia retrovirus developed murine acquired immune-deficiency syndrome (AIDS). Dehydroepiandrosterone (DHEA) and melatonin (MLT) modify immune dysfunction and prevent lipid peroxidation. We investigated whether DHEA and MLT could prevent immune dysfunction, excessive lipid peroxidation, and tissue vitamin E loss induced by retrovirus infection. Retrovirus infection inhibited the release of T helper 1 (Th1) cytokines, stimulated secretion of Th2 cytokines, increased hepatic lipid peroxidation, and induced vitamin E deficiency. Treatment with DHEA or MLT alone, as well as together, largely prevented the reduction of B- and T-cell proliferation as well as of Th1 cytokine secretion caused by retrovirus infection. Supplementation also suppressed the elevated production of Th2 cytokines stimulated by retrovirus infection. DHEA and MLT simultaneously reduced hepatic lipid peroxidation and prevented vitamin E loss. The use of DHEA plus MLT was more effective in preventing retrovirus- induced immune dysfunction than either DHEA or MLT alone. These results suggest that supplementation with DHEA and MLT may prevent cytokine dysregulation, lipid oxidation and tissue vitamin E loss induced by retrovirus infection. Similarly, hormone supplementation also modified immune function and increased tissue vitamin E levels in uninfected mice.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalImmunology
Volume96
Issue number2
DOIs
StatePublished - 1999

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Retroviridae Infections
Dehydroepiandrosterone
Melatonin
Vitamin E
Lipid Peroxidation
Cytokines
Retroviridae
Murine Acquired Immunodeficiency Syndrome
Vitamin E Deficiency
Liver
Inbred C57BL Mouse
Leukemia
Cell Proliferation
Hormones
T-Lymphocytes
Lipids

ASJC Scopus subject areas

  • Immunology

Cite this

Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection. / Zhang, Z.; Araghi-Niknam, M.; Liang, B.; Inserra, P.; Ardestani, S. K.; Jiang, S.; Chow, Hsiao-Hui; Watson, Ronald R.

In: Immunology, Vol. 96, No. 2, 1999, p. 291-297.

Research output: Contribution to journalArticle

Zhang, Z. ; Araghi-Niknam, M. ; Liang, B. ; Inserra, P. ; Ardestani, S. K. ; Jiang, S. ; Chow, Hsiao-Hui ; Watson, Ronald R. / Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection. In: Immunology. 1999 ; Vol. 96, No. 2. pp. 291-297.
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