PREVENTION OF UV IRRADIATION INDUCED SUPPRESSION OF MONOCYTE FUNCTIONS BY RETINOIDS AND CAROTENOIDS in vitro

David J. Schoen, Ronald R. Watson

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Abstract— The effects of stimulation of human peripheral blood monocytes in vitro with retinoids and carotenoids, and subsequent exposure to ultraviolet light of the B wavelength were measured. The compounds were applied to the monocytes in culture for 24 h, and the washed cells were then exposed to UVB light up to 220 J/m2. The compounds tested protected the monocyte from UVB induced damage to phagocytic activity. This protection may be due to the antioxidant or UVB energy‐quenching properties of these compounds. Monocyte cytotoxicity against a melanoma cell line was stimulated by exposure to the retinoids or carotenoids, but a protective effect in vitro against UVB damage was not seen for this cell function.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalPhotochemistry and Photobiology
Volume48
Issue number5
DOIs
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

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