Primary afferent tachykinins are required to experience moderate to intense pain

Yu Qing Cao, Patrick W Mantyh, Elaine J. Carlson, Anne Marie Gillespie, Charles J. Epstein, Allan I. Basbaum

Research output: Contribution to journalArticle

453 Citations (Scopus)

Abstract

The excitatory neurotransmitter glutamate coexists with the peptide known as substance P in primary afferents that respond to painful stimulation. Because blockers of glutamate receptors reliably reduce pain behaviour, it is assumed that 'pain' messages are mediated by glutamate action on dorsal horn neurons. The contribution of substance P, however, is still unclear. We have now disrupted the mouse preprotachykinin A gene (PPT- A), which encodes substance P and a related tachykinin, neurokinin A (ref. 5). We find that although the behavioural response to mildly painful stimuli is intact in these mice, the response to moderate to intense pain is significantly reduced. Neurogenic inflammation, which results from peripheral release of substance P and neurokinin A (ref. 6), is almost absent in the mutant mice. We conclude that the release of tachykinins from primary afferent pain-sensing receptors (nociceptors) is required to produce moderate to intense pain.

Original languageEnglish (US)
Pages (from-to)390-394
Number of pages5
JournalNature
Volume392
Issue number6674
DOIs
StatePublished - Mar 26 1998
Externally publishedYes

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Tachykinins
Substance P
Neurokinin A
Pain
Nociceptors
Glutamic Acid
Neurogenic Inflammation
Posterior Horn Cells
Glutamate Receptors
Neurotransmitter Agents
Peptides
Genes

ASJC Scopus subject areas

  • General

Cite this

Cao, Y. Q., Mantyh, P. W., Carlson, E. J., Gillespie, A. M., Epstein, C. J., & Basbaum, A. I. (1998). Primary afferent tachykinins are required to experience moderate to intense pain. Nature, 392(6674), 390-394. https://doi.org/10.1038/32897

Primary afferent tachykinins are required to experience moderate to intense pain. / Cao, Yu Qing; Mantyh, Patrick W; Carlson, Elaine J.; Gillespie, Anne Marie; Epstein, Charles J.; Basbaum, Allan I.

In: Nature, Vol. 392, No. 6674, 26.03.1998, p. 390-394.

Research output: Contribution to journalArticle

Cao, YQ, Mantyh, PW, Carlson, EJ, Gillespie, AM, Epstein, CJ & Basbaum, AI 1998, 'Primary afferent tachykinins are required to experience moderate to intense pain', Nature, vol. 392, no. 6674, pp. 390-394. https://doi.org/10.1038/32897
Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI. Primary afferent tachykinins are required to experience moderate to intense pain. Nature. 1998 Mar 26;392(6674):390-394. https://doi.org/10.1038/32897
Cao, Yu Qing ; Mantyh, Patrick W ; Carlson, Elaine J. ; Gillespie, Anne Marie ; Epstein, Charles J. ; Basbaum, Allan I. / Primary afferent tachykinins are required to experience moderate to intense pain. In: Nature. 1998 ; Vol. 392, No. 6674. pp. 390-394.
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