Primary biliary tract malignancies

MRI spectrum and mimics with histopathological correlation

Pardeep K. Mittal, Courtney Coursey Moreno, Bobby T Kalb, Ankush Mittal, Juan C. Camacho, Kiran Maddu, Hiroumi D. Kitajima, Brian C. Quigley, Nima Kokabi, William C. Small

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Contrast-enhanced magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP), due to their excellent soft tissue contrasts, have become first-line noninvasive tests in the characterization and detection of both hepatic and pancreaticobiliary pathologies. MRCP is also helpful in detecting the level and cause of obstruction in patients presenting with jaundice. Cholangiocarcinoma (CCA) is the most common primary malignant tumor arising from the bile duct epithelium, with extrahepatic tumors presenting more often than with intrahepatic ones. However, the diagnosis and management of CCA is made more complex by a variety of malignant and benign conditions that resemble CCA, including hepatocellular carcinoma variants such as the fibrolamellar variant of hepatocellular carcinoma, cholangiocellular carcinoma, biliary metastases, hepatic inflammatory pseudotumor, lymphoepithelioma-like carcinoma, confluent fibrosis, primary sclerosis cholangitis, and the secondary sclerosing cholangitis complex. Consequently, knowledge of the underlying risk factors and imaging characteristics of these conditions is important in differentiating between neoplastic and non-neoplastic conditions in order to reach a definite diagnosis. Endoscopic retrograde cholangiopancreatography should be reserved for those patients who require intervention or biopsy for histopathological diagnosis.

Original languageEnglish (US)
Pages (from-to)1520-1557
Number of pages38
JournalAbdominal Imaging
Volume40
Issue number6
DOIs
StatePublished - Nov 22 2014

Fingerprint

Cholangiocarcinoma
Biliary Tract
Magnetic Resonance Cholangiopancreatography
Neoplasms
Plasma Cell Granuloma
Sclerosing Cholangitis
Cholangitis
Endoscopic Retrograde Cholangiopancreatography
Liver
Sclerosis
Jaundice
Bile Ducts
Hepatocellular Carcinoma
Fibrosis
Epithelium
Magnetic Resonance Imaging
Pathology
Neoplasm Metastasis
Carcinoma
Biopsy

Keywords

  • Cholangiocarcinoma (CCA)
  • Magnetic resonance imaging (MRI)
  • Primary sclerosing cholangitis (PSC)

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Mittal, P. K., Moreno, C. C., Kalb, B. T., Mittal, A., Camacho, J. C., Maddu, K., ... Small, W. C. (2014). Primary biliary tract malignancies: MRI spectrum and mimics with histopathological correlation. Abdominal Imaging, 40(6), 1520-1557. https://doi.org/10.1007/s00261-014-0300-0

Primary biliary tract malignancies : MRI spectrum and mimics with histopathological correlation. / Mittal, Pardeep K.; Moreno, Courtney Coursey; Kalb, Bobby T; Mittal, Ankush; Camacho, Juan C.; Maddu, Kiran; Kitajima, Hiroumi D.; Quigley, Brian C.; Kokabi, Nima; Small, William C.

In: Abdominal Imaging, Vol. 40, No. 6, 22.11.2014, p. 1520-1557.

Research output: Contribution to journalArticle

Mittal, PK, Moreno, CC, Kalb, BT, Mittal, A, Camacho, JC, Maddu, K, Kitajima, HD, Quigley, BC, Kokabi, N & Small, WC 2014, 'Primary biliary tract malignancies: MRI spectrum and mimics with histopathological correlation', Abdominal Imaging, vol. 40, no. 6, pp. 1520-1557. https://doi.org/10.1007/s00261-014-0300-0
Mittal, Pardeep K. ; Moreno, Courtney Coursey ; Kalb, Bobby T ; Mittal, Ankush ; Camacho, Juan C. ; Maddu, Kiran ; Kitajima, Hiroumi D. ; Quigley, Brian C. ; Kokabi, Nima ; Small, William C. / Primary biliary tract malignancies : MRI spectrum and mimics with histopathological correlation. In: Abdominal Imaging. 2014 ; Vol. 40, No. 6. pp. 1520-1557.
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