Pro-adhesive extracellular matrix mimic for use in organ-on-a-CHIP

Ariana M. Nicolini, Jeong-Yeol Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pharmacotoxicology studies currently approved by the US FDA use only 2D static cell culture, which is not a good comparison to the complex structure and flow we find in vivo. 3D cell culture systems on microfluidic platforms could transform the way that we evaluate drug efficacy. Incorporation of gelatin electrospun nanofibers, containing submicron particles and cell binding peptides will drastically decrease time necessary for sufficient cell adhesion, proliferation and differentiation in organ-on-a-chip (OOC) research. Moreover, this scaffolding will improve realism of OOC by more closely mimicking native extracellular matrix (ECM). These improvements to the technology will provide results of cellular behavior in response to external stimuli, thus increasing realism in pharmaceutical testing. In this work we created an ECM-like substrate, which structurally and chemically mimics the basement structure healthy tissue, in a microfluidic system.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages760-762
Number of pages3
ISBN (Print)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Derjaguin-Landau-Verwey-Overbeek theory
  • Electrospinning
  • Gelatin
  • RGD ligand

ASJC Scopus subject areas

  • Control and Systems Engineering

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