Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): A highly selective, nonpeptide δ opioid receptor agonist

Silvia N. Calderon, Richard B. Rothman, Frank Porreca, Judith L. Flippen-Anderson, Robert W. McNutt, Heng Xu, Larren E. Smith, Edward J. Bilsky, Peg Davis, Kenner C. Rice

Research output: Contribution to journalArticle

210 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)2125-2128
Number of pages4
JournalJournal of Medicinal Chemistry
Volume37
Issue number14
StatePublished - 1994

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Piperazines
Benzamides
delta Opioid Receptor
Stereoisomerism
mu Opioid Receptor
Narcotics
Opioid Receptors
Structure-Activity Relationship
Guinea Pigs
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide
rebemide

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80) : A highly selective, nonpeptide δ opioid receptor agonist. / Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; McNutt, Robert W.; Xu, Heng; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Rice, Kenner C.

In: Journal of Medicinal Chemistry, Vol. 37, No. 14, 1994, p. 2125-2128.

Research output: Contribution to journalArticle

Calderon, Silvia N. ; Rothman, Richard B. ; Porreca, Frank ; Flippen-Anderson, Judith L. ; McNutt, Robert W. ; Xu, Heng ; Smith, Larren E. ; Bilsky, Edward J. ; Davis, Peg ; Rice, Kenner C. / Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80) : A highly selective, nonpeptide δ opioid receptor agonist. In: Journal of Medicinal Chemistry. 1994 ; Vol. 37, No. 14. pp. 2125-2128.
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