S-(trans-1,2-dichlorovinyl)-L-cysteine (DCVC) is a recognized nephrotoxin. To investigate the genotoxic effects of DCVC on the kidney, DNA strand breaks were measured as an indicator of DCVC induced damage. To ascertain if bioactivation of DCVC occured in the kidney, 3 experimental systems were used: in vivo; perfused kidneys; an isolated proximal tubules of albino male rabbitsl. A dose-dependent increase in strand breaks in the kidney tubular DNA occured after in vivo dosing with 5-100 mg/kg DCVC and after in vitro exposure to 10-5-10-2 M DCVC. These results demonstrate the genotoxic effect of this compound on renal tissue.
- Single-strand breaks
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