Production of IgG autoantibodies to TCRs in mice infected with the retrovirus LP-BM5

Keivan Dehghanpisheh, Dennis Huang, Samuel F. Schluter, Ronald R. Watson, J. J. Marchalonis

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Autoantibodies (AAbs) directed against particular segments of the variable region of TCR β chains occur in normal humans and in certain autoimmune diseases, but the factors regulating the appearance of such antibodies are unknown. We report that AAbs binding a peptide determinant corresponding to the CDR1 of the Vβ domain are elevated in C57BL/6 mice following infection with the LP-BM5 murlne leukemia retrovirus mixture, a treatment used to induce murine AIDS. The elevation of the level of these AAbs is an early event following retrovlral infection which corresponds in part to the general polyclonal activation of the B cells, but a selectivity for particular Vβ sequences is apparent later. This suggests that the appearance of these antibodies may play a part in the subsequent development of immunodeficiency. Since the antibodies studied are of the IgG isotype, both T cells and B cells are involved in their elaboration.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalInternational Immunology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1995

Keywords

  • Immunochemistry
  • MAIDS
  • Synthetic peptides
  • Vβ antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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