Profiling small molecule inhibitors against helix-receptor interactions

The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

Jason R. Porter, Mark R. Helmers, Ping Wang, Jennifer L. Furman, Stephen T. Joy, Paramjit S. Arora, Indraneel Ghosh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

Original languageEnglish (US)
Pages (from-to)8020-8022
Number of pages3
JournalChemical Communications
Volume46
Issue number42
DOIs
StatePublished - Nov 14 2010

Fingerprint

Proteins
Molecules

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Profiling small molecule inhibitors against helix-receptor interactions : The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. / Porter, Jason R.; Helmers, Mark R.; Wang, Ping; Furman, Jennifer L.; Joy, Stephen T.; Arora, Paramjit S.; Ghosh, Indraneel.

In: Chemical Communications, Vol. 46, No. 42, 14.11.2010, p. 8020-8022.

Research output: Contribution to journalArticle

Porter, Jason R. ; Helmers, Mark R. ; Wang, Ping ; Furman, Jennifer L. ; Joy, Stephen T. ; Arora, Paramjit S. ; Ghosh, Indraneel. / Profiling small molecule inhibitors against helix-receptor interactions : The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. In: Chemical Communications. 2010 ; Vol. 46, No. 42. pp. 8020-8022.
@article{fef008b5e394471d8cb5d3791d8623d5,
title = "Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2",
abstract = "We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.",
author = "Porter, {Jason R.} and Helmers, {Mark R.} and Ping Wang and Furman, {Jennifer L.} and Joy, {Stephen T.} and Arora, {Paramjit S.} and Indraneel Ghosh",
year = "2010",
month = "11",
day = "14",
doi = "10.1039/c0cc02969f",
language = "English (US)",
volume = "46",
pages = "8020--8022",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "42",

}

TY - JOUR

T1 - Profiling small molecule inhibitors against helix-receptor interactions

T2 - The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

AU - Porter, Jason R.

AU - Helmers, Mark R.

AU - Wang, Ping

AU - Furman, Jennifer L.

AU - Joy, Stephen T.

AU - Arora, Paramjit S.

AU - Ghosh, Indraneel

PY - 2010/11/14

Y1 - 2010/11/14

N2 - We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

AB - We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

UR - http://www.scopus.com/inward/record.url?scp=77958455528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958455528&partnerID=8YFLogxK

U2 - 10.1039/c0cc02969f

DO - 10.1039/c0cc02969f

M3 - Article

VL - 46

SP - 8020

EP - 8022

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 42

ER -