Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuries

Hasan B. Alam, Zheng Chen, Yongqing Li, George Velmahos, Marc DeMoya, Christopher E. Keller, Kevin Toruno, Tina Mehrani, Peter M Rhee, Konstantinos Spaniolas

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Rapid induction of profound hypothermia can improve survival from uncontrolled lethal hemorrhage. However, the optimal depth of hypothermia in this setting remains unknown. This experiment was designed to compare the impact of deep (15°C), profound (10°C), and ultraprofound (5°C) hypothermia on survival and organ functions. Methods: Uncontrolled lethal hemorrhage was induced in 32 swine (80-120 lb) by creating an iliac artery and vein injury, followed 30 minutes later by laceration of the descending thoracic aorta. Hypothermia was induced rapidly (2°C/min) by infusing cold organ preservation solution into the aorta through a thoracotomy. The experimental groups were (n = 8 per group): a normothermic control, and 3 hypothermic groups in which the core temperature was reduced to 15°C, 10°C, and 5°C. Vascular injuries were repaired during 60 minutes of hypothermia. Animals were then rewarmed (0.5°C/min) and resuscitated on cardiopulmonary bypass, and monitored for 6 weeks for neurologic deficits, cognitive function, and organ dysfunction. Results: All normothermic animals died, whereas 6-week survival rates for the 15°C, 10°C, and 5°C groups were 62.5%, 87.5%, and 25%, respectively (P < .05: normothermic vs 15°C and 10°C; 10°C vs 5°C). The surviving animals from the 15°C and 10°C groups were neurologically intact, displayed normal learning capacity, and had no long-term organ dysfunction. The survivors from the 5°C group displayed slower recovery and impaired cognitive functions. Conclusions: In a model of lethal injuries, rapid induction of profound hypothermia can prevent death. The depth of hypothermia influences survival, with a better outcome associated with a core temperature of 10°C compared with 5°C.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalSurgery
Volume140
Issue number2
DOIs
StatePublished - Aug 2006
Externally publishedYes

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Hypothermia
Swine
Wounds and Injuries
Thoracic Aorta
Cognition
Organ Preservation Solutions
Hemorrhage
Iliac Vein
Induced Hypothermia
Tissue Survival
Temperature
Lacerations
Iliac Artery
Vascular System Injuries
Thoracotomy
Neurologic Manifestations
Cardiopulmonary Bypass
Aorta
Learning

ASJC Scopus subject areas

  • Surgery

Cite this

Alam, H. B., Chen, Z., Li, Y., Velmahos, G., DeMoya, M., Keller, C. E., ... Spaniolas, K. (2006). Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuries. Surgery, 140(2), 307-314. https://doi.org/10.1016/j.surg.2006.03.015

Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuries. / Alam, Hasan B.; Chen, Zheng; Li, Yongqing; Velmahos, George; DeMoya, Marc; Keller, Christopher E.; Toruno, Kevin; Mehrani, Tina; Rhee, Peter M; Spaniolas, Konstantinos.

In: Surgery, Vol. 140, No. 2, 08.2006, p. 307-314.

Research output: Contribution to journalArticle

Alam, HB, Chen, Z, Li, Y, Velmahos, G, DeMoya, M, Keller, CE, Toruno, K, Mehrani, T, Rhee, PM & Spaniolas, K 2006, 'Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuries', Surgery, vol. 140, no. 2, pp. 307-314. https://doi.org/10.1016/j.surg.2006.03.015
Alam, Hasan B. ; Chen, Zheng ; Li, Yongqing ; Velmahos, George ; DeMoya, Marc ; Keller, Christopher E. ; Toruno, Kevin ; Mehrani, Tina ; Rhee, Peter M ; Spaniolas, Konstantinos. / Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuries. In: Surgery. 2006 ; Vol. 140, No. 2. pp. 307-314.
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abstract = "Background: Rapid induction of profound hypothermia can improve survival from uncontrolled lethal hemorrhage. However, the optimal depth of hypothermia in this setting remains unknown. This experiment was designed to compare the impact of deep (15°C), profound (10°C), and ultraprofound (5°C) hypothermia on survival and organ functions. Methods: Uncontrolled lethal hemorrhage was induced in 32 swine (80-120 lb) by creating an iliac artery and vein injury, followed 30 minutes later by laceration of the descending thoracic aorta. Hypothermia was induced rapidly (2°C/min) by infusing cold organ preservation solution into the aorta through a thoracotomy. The experimental groups were (n = 8 per group): a normothermic control, and 3 hypothermic groups in which the core temperature was reduced to 15°C, 10°C, and 5°C. Vascular injuries were repaired during 60 minutes of hypothermia. Animals were then rewarmed (0.5°C/min) and resuscitated on cardiopulmonary bypass, and monitored for 6 weeks for neurologic deficits, cognitive function, and organ dysfunction. Results: All normothermic animals died, whereas 6-week survival rates for the 15°C, 10°C, and 5°C groups were 62.5{\%}, 87.5{\%}, and 25{\%}, respectively (P < .05: normothermic vs 15°C and 10°C; 10°C vs 5°C). The surviving animals from the 15°C and 10°C groups were neurologically intact, displayed normal learning capacity, and had no long-term organ dysfunction. The survivors from the 5°C group displayed slower recovery and impaired cognitive functions. Conclusions: In a model of lethal injuries, rapid induction of profound hypothermia can prevent death. The depth of hypothermia influences survival, with a better outcome associated with a core temperature of 10°C compared with 5°C.",
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T1 - Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuries

AU - Alam, Hasan B.

AU - Chen, Zheng

AU - Li, Yongqing

AU - Velmahos, George

AU - DeMoya, Marc

AU - Keller, Christopher E.

AU - Toruno, Kevin

AU - Mehrani, Tina

AU - Rhee, Peter M

AU - Spaniolas, Konstantinos

PY - 2006/8

Y1 - 2006/8

N2 - Background: Rapid induction of profound hypothermia can improve survival from uncontrolled lethal hemorrhage. However, the optimal depth of hypothermia in this setting remains unknown. This experiment was designed to compare the impact of deep (15°C), profound (10°C), and ultraprofound (5°C) hypothermia on survival and organ functions. Methods: Uncontrolled lethal hemorrhage was induced in 32 swine (80-120 lb) by creating an iliac artery and vein injury, followed 30 minutes later by laceration of the descending thoracic aorta. Hypothermia was induced rapidly (2°C/min) by infusing cold organ preservation solution into the aorta through a thoracotomy. The experimental groups were (n = 8 per group): a normothermic control, and 3 hypothermic groups in which the core temperature was reduced to 15°C, 10°C, and 5°C. Vascular injuries were repaired during 60 minutes of hypothermia. Animals were then rewarmed (0.5°C/min) and resuscitated on cardiopulmonary bypass, and monitored for 6 weeks for neurologic deficits, cognitive function, and organ dysfunction. Results: All normothermic animals died, whereas 6-week survival rates for the 15°C, 10°C, and 5°C groups were 62.5%, 87.5%, and 25%, respectively (P < .05: normothermic vs 15°C and 10°C; 10°C vs 5°C). The surviving animals from the 15°C and 10°C groups were neurologically intact, displayed normal learning capacity, and had no long-term organ dysfunction. The survivors from the 5°C group displayed slower recovery and impaired cognitive functions. Conclusions: In a model of lethal injuries, rapid induction of profound hypothermia can prevent death. The depth of hypothermia influences survival, with a better outcome associated with a core temperature of 10°C compared with 5°C.

AB - Background: Rapid induction of profound hypothermia can improve survival from uncontrolled lethal hemorrhage. However, the optimal depth of hypothermia in this setting remains unknown. This experiment was designed to compare the impact of deep (15°C), profound (10°C), and ultraprofound (5°C) hypothermia on survival and organ functions. Methods: Uncontrolled lethal hemorrhage was induced in 32 swine (80-120 lb) by creating an iliac artery and vein injury, followed 30 minutes later by laceration of the descending thoracic aorta. Hypothermia was induced rapidly (2°C/min) by infusing cold organ preservation solution into the aorta through a thoracotomy. The experimental groups were (n = 8 per group): a normothermic control, and 3 hypothermic groups in which the core temperature was reduced to 15°C, 10°C, and 5°C. Vascular injuries were repaired during 60 minutes of hypothermia. Animals were then rewarmed (0.5°C/min) and resuscitated on cardiopulmonary bypass, and monitored for 6 weeks for neurologic deficits, cognitive function, and organ dysfunction. Results: All normothermic animals died, whereas 6-week survival rates for the 15°C, 10°C, and 5°C groups were 62.5%, 87.5%, and 25%, respectively (P < .05: normothermic vs 15°C and 10°C; 10°C vs 5°C). The surviving animals from the 15°C and 10°C groups were neurologically intact, displayed normal learning capacity, and had no long-term organ dysfunction. The survivors from the 5°C group displayed slower recovery and impaired cognitive functions. Conclusions: In a model of lethal injuries, rapid induction of profound hypothermia can prevent death. The depth of hypothermia influences survival, with a better outcome associated with a core temperature of 10°C compared with 5°C.

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