Prognostic Criteria for Squamous Cell Cancer of the Skin

Vanessa Jensen, Anil P Rama Rao, Aaron Smith, Menaka Raju, Christopher S Wendel, Monika Schmelz, William Leyva, James A Warneke, Robert S Krouse

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Non-well-differentiated cutaneous squamous cell carcinomas may display a more aggressive behavior. It is important to better define prognostic criteria for these tumors. Methods: This was a retrospective case-control analysis of a squamous cell carcinoma database. Patients with non-well-differentiated and well-differentiated tumors were matched based on site of tumor, age, and immunocompromised status. Comparisons included demographics, histology, immunohistochemical protein expressions (Ki-67, p53, E-cadherin, cyclin D1), and clinical outcomes. Results: Demographic features were similar between cases (n = 30) and controls (n = 30). Non-well-differentiated tumors were larger (1.8 cm versus 1.3 cm, P = 0.08), deeper (0.81 cm versus 0.32 cm, P < 0.0001), and had greater recurrence (P = 0.003). Non-well-differentiated tumors showed increased proliferation rate, Ki-67 index (77% versus 61%, P = 0.001); no significant difference in activity of p53, E-cadherin, and cyclin D1 between the two groups. Conclusions: Tumor differentiation and depth are important pathologic and prognostic criteria for cutaneous squamous cell carcinoma. Immunohistochemistry helps describe patterns of biomarker protein expression and may exemplify aggressive subtypes.

Original languageEnglish (US)
Pages (from-to)509-516
Number of pages8
JournalJournal of Surgical Research
Volume159
Issue number1
DOIs
StatePublished - Mar 2010

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Squamous Cell Neoplasms
Skin Neoplasms
Squamous Cell Carcinoma
Neoplasms
Cyclin D1
Cadherins
Demography
Skin
Histology
Proteins
Biomarkers
Immunohistochemistry
Databases
Recurrence

Keywords

  • carcinoma
  • cutaneous
  • histopathology
  • immunochemistry
  • prognosis
  • squamous

ASJC Scopus subject areas

  • Surgery

Cite this

Prognostic Criteria for Squamous Cell Cancer of the Skin. / Jensen, Vanessa; Rama Rao, Anil P; Smith, Aaron; Raju, Menaka; Wendel, Christopher S; Schmelz, Monika; Leyva, William; Warneke, James A; Krouse, Robert S.

In: Journal of Surgical Research, Vol. 159, No. 1, 03.2010, p. 509-516.

Research output: Contribution to journalArticle

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AU - Smith, Aaron

AU - Raju, Menaka

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AU - Schmelz, Monika

AU - Leyva, William

AU - Warneke, James A

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