Prognostic value of concordant seizure focus localizing data in the selection of temporal lobectomy candidates

David M Labiner, Martin E. Weinandt, Charles J. Brainerd, Geoffrey L Ahern, Anne M. Herring, Miguel A. Melgar

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study was performed to test the hypotheses that (a) resection of the temporal lobe epileptic focus, amenable to noninvasive as opposed to invasive localization, is associated with superior seizure outcome and (b) that quadruple (versus lesser degrees of) concordance of seizure focus localizing data predicts superior seizure-free outcome. Eighty-three patients underwent invasive (subdural-EEG) and/or noninvasive (video/scalp-EEG, SPECT, PET, MRI, neuropsychological testing) evaluation. All patients underwent anterior temporal lobectomy and amygdalohippocampectomy (A TL/AH) and seizure outcome was assessed at minimum one-year follow-up. At 34.8±2.5 months following ATL/AH, outcome was superior for patients in whom the seizure focus was amenable to noninvasive compared to invasive localization (80% versus 40% seizure-free, X2= 14.03, p < 0.05). Seizure outcome was superior for patients with quadruple, compared to all lesser degrees of, concordance of seizure focus localizing data (85% versus 51% seizure-free, X2 = 7.34, p < 0.05). Post-A TL/AH, seizure outcome is superior in patients (1) harboring an epileptic focus amenable to noninvasive localization and (2) with quadruple concordance of seizure focus localizing data. These findings support the development of temporal lobectomy selection criteria including up to four invasive and/or noninvasive concordant seizure focus localizing techniques.

Original languageEnglish (US)
Pages (from-to)747-755
Number of pages9
JournalNeurological Research
Volume24
Issue number8
DOIs
StatePublished - Dec 2002

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Seizures
Anterior Temporal Lobectomy
Electroencephalography
Temporal Lobe
Single-Photon Emission-Computed Tomography
Scalp
Patient Selection

Keywords

  • Electroencephalography
  • Temporal lobe epilepsy
  • Temporal lobectomy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Prognostic value of concordant seizure focus localizing data in the selection of temporal lobectomy candidates. / Labiner, David M; Weinandt, Martin E.; Brainerd, Charles J.; Ahern, Geoffrey L; Herring, Anne M.; Melgar, Miguel A.

In: Neurological Research, Vol. 24, No. 8, 12.2002, p. 747-755.

Research output: Contribution to journalArticle

Labiner, David M ; Weinandt, Martin E. ; Brainerd, Charles J. ; Ahern, Geoffrey L ; Herring, Anne M. ; Melgar, Miguel A. / Prognostic value of concordant seizure focus localizing data in the selection of temporal lobectomy candidates. In: Neurological Research. 2002 ; Vol. 24, No. 8. pp. 747-755.
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