Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals

Surojit Sarkar, Yevgeniy Yuzefpolskiy, Hanxi Xiao, Florian M. Baumann, Soojin Yim, David J. Lee, Dominik Schenten, Vandana Kalia

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

IL-1, generally considered an amplifier of adaptive immune responses, has been proposed for use as adjuvant during immunization with weak immunogens. However, its effects on memory T cell function remain largely undefined. Using the murine model of acute viral infection, in this paper, we show that in addition to augmenting the size of the Ag-specific pool, IL-1 signals act directly on CD8 T cells to promote the quality of effector and memory responses. Ablation of IL-1R1 or MyD88 signaling in T cells led to functional impairment; both the ability to produce multiple cytokines on a per cell basis (polyfunctionality) and the potential for recall proliferation in response to antigenic restimulation were compromised. IL-1 supplementation during priming augmented the expansion of Ag-specific CD8 T cells through the MyD88-IRAK1/4 axis, resulting in a larger memory pool capable of robust secondary expansion in response to rechallange. Together, these findings demonstrate a critical role of the IL-1-MyD88 axis in programming the quantity and quality of memory CD8 T cell responses and support the notion that IL-1 supplementation may be exploited to enhance adoptive T cell therapies against cancers and chronic infections. The Journ Al of Immunology, 2018, 201: 3641-3650.

Original languageEnglish (US)
Pages (from-to)3641-3650
Number of pages10
JournalJournal of Immunology
Volume201
Issue number12
DOIs
StatePublished - Dec 15 2018
Externally publishedYes

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Interleukin-1
T-Lymphocytes
Aptitude
Adaptive Immunity
Virus Diseases
Cell- and Tissue-Based Therapy
Allergy and Immunology
Immunization
Cytokines
Infection
Neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., ... Kalia, V. (2018). Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals. Journal of Immunology, 201(12), 3641-3650. https://doi.org/10.4049/jimmunol.1800906

Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals. / Sarkar, Surojit; Yuzefpolskiy, Yevgeniy; Xiao, Hanxi; Baumann, Florian M.; Yim, Soojin; Lee, David J.; Schenten, Dominik; Kalia, Vandana.

In: Journal of Immunology, Vol. 201, No. 12, 15.12.2018, p. 3641-3650.

Research output: Contribution to journalArticle

Sarkar, S, Yuzefpolskiy, Y, Xiao, H, Baumann, FM, Yim, S, Lee, DJ, Schenten, D & Kalia, V 2018, 'Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals', Journal of Immunology, vol. 201, no. 12, pp. 3641-3650. https://doi.org/10.4049/jimmunol.1800906
Sarkar S, Yuzefpolskiy Y, Xiao H, Baumann FM, Yim S, Lee DJ et al. Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals. Journal of Immunology. 2018 Dec 15;201(12):3641-3650. https://doi.org/10.4049/jimmunol.1800906
Sarkar, Surojit ; Yuzefpolskiy, Yevgeniy ; Xiao, Hanxi ; Baumann, Florian M. ; Yim, Soojin ; Lee, David J. ; Schenten, Dominik ; Kalia, Vandana. / Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals. In: Journal of Immunology. 2018 ; Vol. 201, No. 12. pp. 3641-3650.
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