Progressive transformation of hippocampal neuronal representations in "morphed" environments

Jill K. Leutgeb, Stefan Leutgeb, Alessandro Treves, Retsina Meyer, Carol A. Barnes, Bruce L. McNaughton, May Britt Moser, Edvard I. Moser

Research output: Contribution to journalArticle

215 Scopus citations

Abstract

Hippocampal neural codes for different, familiar environments are thought to reflect distinct attractor states, possibly implemented in the recurrent CA3 network. A defining property of an attractor network is its ability to undergo sharp and coherent transitions between pre-established (learned) representations when the inputs to the network are changed. To determine whether hippocampal neuronal ensembles exhibit such discontinuities, we recorded in CA3 and CA1 when a familiar square recording enclosure was morphed in quantifiable steps into a familiar circular enclosure while leaving other inputs constant. We observed a gradual noncoherent progression from the initial to the final network state. In CA3, the transformation was accompanied by significant hysteresis, resulting in more similar end states than when only square and circle were presented. These observations suggest that hippocampal cell assemblies are capable of incremental plastic deformation, with incongruous information being incorporated into pre-existing representations.

Original languageEnglish (US)
Pages (from-to)345-358
Number of pages14
JournalNeuron
Volume48
Issue number2
DOIs
StatePublished - Oct 20 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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    Leutgeb, J. K., Leutgeb, S., Treves, A., Meyer, R., Barnes, C. A., McNaughton, B. L., Moser, M. B., & Moser, E. I. (2005). Progressive transformation of hippocampal neuronal representations in "morphed" environments. Neuron, 48(2), 345-358. https://doi.org/10.1016/j.neuron.2005.09.007